Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma

Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, s...

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Autores principales: Azizi, Alexander A., Hadjinicolaou, Andreas V., Goncalves, Carla, Duckworth, Adam, Basu, Bristi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545907/
https://www.ncbi.nlm.nih.gov/pubmed/33102226
http://dx.doi.org/10.3389/fonc.2020.570958
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author Azizi, Alexander A.
Hadjinicolaou, Andreas V.
Goncalves, Carla
Duckworth, Adam
Basu, Bristi
author_facet Azizi, Alexander A.
Hadjinicolaou, Andreas V.
Goncalves, Carla
Duckworth, Adam
Basu, Bristi
author_sort Azizi, Alexander A.
collection PubMed
description Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC.
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spelling pubmed-75459072020-10-22 Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma Azizi, Alexander A. Hadjinicolaou, Andreas V. Goncalves, Carla Duckworth, Adam Basu, Bristi Front Oncol Oncology Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7545907/ /pubmed/33102226 http://dx.doi.org/10.3389/fonc.2020.570958 Text en Copyright © 2020 Azizi, Hadjinicolaou, Goncalves, Duckworth and Basu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Azizi, Alexander A.
Hadjinicolaou, Andreas V.
Goncalves, Carla
Duckworth, Adam
Basu, Bristi
Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title_full Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title_fullStr Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title_full_unstemmed Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title_short Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
title_sort update on the genetics of and systemic therapy options for combined hepatocellular cholangiocarcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545907/
https://www.ncbi.nlm.nih.gov/pubmed/33102226
http://dx.doi.org/10.3389/fonc.2020.570958
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