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Dexamethasone rescues TGF-β1-mediated β(2)-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Glucocorticoids (GCs) and β(2)-adrenergic receptor (β(2)AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflammation and airway hyperresponsiveness that define asthma. Our previous studies showe...

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Detalles Bibliográficos
Autores principales:	Chung, Elena, Ojiaku, Christie A., Cao, Gaoyuan, Parikh, Vishal, Deeney, Brian, Xu, Shengjie, Wang, Serena, Panettieri, Reynold A., Koziol-White, Cynthia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545943/ https://www.ncbi.nlm.nih.gov/pubmed/33032603 http://dx.doi.org/10.1186/s12931-020-01522-w

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