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Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition
BACKGROUND: Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic antitumor interaction between two well-known drugs used for years in clinical pr...
Autores principales: | Iannelli, Federica, Roca, Maria Serena, Lombardi, Rita, Ciardiello, Chiara, Grumetti, Laura, De Rienzo, Simona, Moccia, Tania, Vitagliano, Carlo, Sorice, Angela, Costantini, Susan, Milone, Maria Rita, Pucci, Biagio, Leone, Alessandra, Di Gennaro, Elena, Mancini, Rita, Ciliberto, Gennaro, Bruzzese, Francesca, Budillon, Alfredo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545949/ https://www.ncbi.nlm.nih.gov/pubmed/33032653 http://dx.doi.org/10.1186/s13046-020-01723-7 |
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