Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examp...

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Autores principales: Sikora, Adam, Zielonka, Jacek, Dębowska, Karolina, Michalski, Radosław, Smulik-Izydorczyk, Renata, Pięta, Jakub, Podsiadły, Radosław, Artelska, Angelika, Pierzchała, Karolina, Kalyanaraman, Balaraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545953/
https://www.ncbi.nlm.nih.gov/pubmed/33102447
http://dx.doi.org/10.3389/fchem.2020.580899
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author Sikora, Adam
Zielonka, Jacek
Dębowska, Karolina
Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Podsiadły, Radosław
Artelska, Angelika
Pierzchała, Karolina
Kalyanaraman, Balaraman
author_facet Sikora, Adam
Zielonka, Jacek
Dębowska, Karolina
Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Podsiadły, Radosław
Artelska, Angelika
Pierzchała, Karolina
Kalyanaraman, Balaraman
author_sort Sikora, Adam
collection PubMed
description Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments.
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spelling pubmed-75459532020-10-22 Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology Sikora, Adam Zielonka, Jacek Dębowska, Karolina Michalski, Radosław Smulik-Izydorczyk, Renata Pięta, Jakub Podsiadły, Radosław Artelska, Angelika Pierzchała, Karolina Kalyanaraman, Balaraman Front Chem Chemistry Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7545953/ /pubmed/33102447 http://dx.doi.org/10.3389/fchem.2020.580899 Text en Copyright © 2020 Sikora, Zielonka, Dębowska, Michalski, Smulik-Izydorczyk, Pięta, Podsiadły, Artelska, Pierzchała and Kalyanaraman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Sikora, Adam
Zielonka, Jacek
Dębowska, Karolina
Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Podsiadły, Radosław
Artelska, Angelika
Pierzchała, Karolina
Kalyanaraman, Balaraman
Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title_full Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title_fullStr Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title_full_unstemmed Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title_short Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
title_sort boronate-based probes for biological oxidants: a novel class of molecular tools for redox biology
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545953/
https://www.ncbi.nlm.nih.gov/pubmed/33102447
http://dx.doi.org/10.3389/fchem.2020.580899
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