ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22(phox) activation in Aβ-induced retinal pigment epithelial cell injury

Rationale: Amyloid β (Aβ) deposition, an essential pathological process in age-related macular degeneration (AMD), causes retinal pigment epithelium (RPE) degeneration driven mostly by oxidative stress. However, despite intense investigations, the extent to which overoxidation contributes to Aβ-medi...

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Detalles Bibliográficos
Autores principales: Sun, Junran, Chen, Jieqiong, Li, Tong, Huang, Peirong, Li, Jie, Shen, Mengxi, Gao, Min, Sun, Yang, Liang, Jian, Li, Xiaomeng, Wang, Yimin, Xiao, Yushu, Shi, Xiang, Hu, Yifan, Feng, Jingyang, Jia, Huixun, Liu, Te, Sun, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546003/
https://www.ncbi.nlm.nih.gov/pubmed/33052238
http://dx.doi.org/10.7150/thno.48064

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