High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy

BACKGROUND: Globus pallidus internus (GPi) deep brain stimulation (DBS) is widely used in patients with isolated dystonia; however, its use remains controversial in patients with acquired dystonia and cerebral palsy. CASE PRESENTATION: We report the first case of a cerebral palsy patient, who failed...

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Autores principales: Lin, Suzhen, Zhang, Chencheng, Li, Hongxia, Wang, Yuhan, Wu, Yunhao, Wang, Tao, Pan, Yixin, Sun, Bomin, Wu, Yiwen, Li, Dianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546102/
https://www.ncbi.nlm.nih.gov/pubmed/33101764
http://dx.doi.org/10.5334/tohm.551
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author Lin, Suzhen
Zhang, Chencheng
Li, Hongxia
Wang, Yuhan
Wu, Yunhao
Wang, Tao
Pan, Yixin
Sun, Bomin
Wu, Yiwen
Li, Dianyou
author_facet Lin, Suzhen
Zhang, Chencheng
Li, Hongxia
Wang, Yuhan
Wu, Yunhao
Wang, Tao
Pan, Yixin
Sun, Bomin
Wu, Yiwen
Li, Dianyou
author_sort Lin, Suzhen
collection PubMed
description BACKGROUND: Globus pallidus internus (GPi) deep brain stimulation (DBS) is widely used in patients with isolated dystonia; however, its use remains controversial in patients with acquired dystonia and cerebral palsy. CASE PRESENTATION: We report the first case of a cerebral palsy patient, who failed to recover 2 years after GPi DBS; DBS was administered on both superior cerebellar peduncles (SCPs) and dentate nuclei (DNs). The monopolar stimulation results suggested that DBS was better administered via the SCPs than via the DNs. At six months follow-up, the patient exhibited a significant improvement of dystonia and spasticity, as well as in her quality of life. DISCUSSION: SCP DBS may be a potential treatment for cerebral palsy patients with dystonia and spasticity who do not respond well to GPi DBS.
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spelling pubmed-75461022020-10-22 High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy Lin, Suzhen Zhang, Chencheng Li, Hongxia Wang, Yuhan Wu, Yunhao Wang, Tao Pan, Yixin Sun, Bomin Wu, Yiwen Li, Dianyou Tremor Other Hyperkinet Mov (N Y) Case Report BACKGROUND: Globus pallidus internus (GPi) deep brain stimulation (DBS) is widely used in patients with isolated dystonia; however, its use remains controversial in patients with acquired dystonia and cerebral palsy. CASE PRESENTATION: We report the first case of a cerebral palsy patient, who failed to recover 2 years after GPi DBS; DBS was administered on both superior cerebellar peduncles (SCPs) and dentate nuclei (DNs). The monopolar stimulation results suggested that DBS was better administered via the SCPs than via the DNs. At six months follow-up, the patient exhibited a significant improvement of dystonia and spasticity, as well as in her quality of life. DISCUSSION: SCP DBS may be a potential treatment for cerebral palsy patients with dystonia and spasticity who do not respond well to GPi DBS. Ubiquity Press 2020-10-07 /pmc/articles/PMC7546102/ /pubmed/33101764 http://dx.doi.org/10.5334/tohm.551 Text en Copyright: © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Lin, Suzhen
Zhang, Chencheng
Li, Hongxia
Wang, Yuhan
Wu, Yunhao
Wang, Tao
Pan, Yixin
Sun, Bomin
Wu, Yiwen
Li, Dianyou
High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title_full High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title_fullStr High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title_full_unstemmed High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title_short High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
title_sort high frequency deep brain stimulation of superior cerebellar peduncles in a patient with cerebral palsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546102/
https://www.ncbi.nlm.nih.gov/pubmed/33101764
http://dx.doi.org/10.5334/tohm.551
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