Development of CNS metastases in breast cancer patients treated with curative intent: a case–control study

BACKGROUND: The aim of this study was to identify risk factors that may predispose breast cancer patients to the development of CNS metastases. MATERIALS & METHODS: We conducted a matched case–control study of breast cancer patients treated with surgery with curative intent. A total of 71 cases...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Katherine, Swartz, Leigh K, Gill, Anoop, Fang, Fang, Kidwell, Kelley M, Morikawa, Aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546155/
https://www.ncbi.nlm.nih.gov/pubmed/32945179
http://dx.doi.org/10.2217/cns-2020-0012
Descripción
Sumario:BACKGROUND: The aim of this study was to identify risk factors that may predispose breast cancer patients to the development of CNS metastases. MATERIALS & METHODS: We conducted a matched case–control study of breast cancer patients treated with surgery with curative intent. A total of 71 cases and 71 controls were analyzed, matched by year of surgery. RESULTS: In our multivariable model, positive lymph node status (odds ratio [OR]: 5.08; CI: 2.04–12.65), the use of neoadjuvant chemotherapy (OR: 6.02; CI: 2.06–17.57) and triple-negative breast cancer (OR: 5.44; CI: 1.99–14.90) were statistically significant predictors of the development of CNS metastases. CONCLUSION: Women with certain risk factors have an increased odds of developing CNS metastases and evaluation of utility in brain metastases screening should be considered.

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