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Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells

Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that: 1) cardiovascular tissues and endothelial cells ex...

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Autores principales: Ahmetaj-Shala, Blerina, Vaja, Ricky, Atanur, Santosh S., George, Peter M., Kirkby, Nicholas S., Mitchell, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546186/
https://www.ncbi.nlm.nih.gov/pubmed/33073064
http://dx.doi.org/10.1016/j.jacbts.2020.09.010
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author Ahmetaj-Shala, Blerina
Vaja, Ricky
Atanur, Santosh S.
George, Peter M.
Kirkby, Nicholas S.
Mitchell, Jane A.
author_facet Ahmetaj-Shala, Blerina
Vaja, Ricky
Atanur, Santosh S.
George, Peter M.
Kirkby, Nicholas S.
Mitchell, Jane A.
author_sort Ahmetaj-Shala, Blerina
collection PubMed
description Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that: 1) cardiovascular tissues and endothelial cells express putative genes for severe acute respiratory syndrome coronavirus-2 infection, including angiotensin-converting enzyme 2 (ACE2) and basigin (BSG); 2) severe acute respiratory syndrome coronavirus-2 receptor pathways ACE2/transmembrane serine protease 2 and BSG/peptidylprolyl isomerase B(A) polarize to lung/epithelium and vessel/endothelium, respectively; 3) expression of host genes is relatively stable with age; and 4) notable exceptions are ACE2, which decreases with age in some tissues, and BSG, which increases with age in endothelial cells, suggesting that BSG expression in the vasculature may explain the heightened risk for severe disease with age.
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spelling pubmed-75461862020-10-13 Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells Ahmetaj-Shala, Blerina Vaja, Ricky Atanur, Santosh S. George, Peter M. Kirkby, Nicholas S. Mitchell, Jane A. JACC Basic Transl Sci Preclinical Research Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that: 1) cardiovascular tissues and endothelial cells express putative genes for severe acute respiratory syndrome coronavirus-2 infection, including angiotensin-converting enzyme 2 (ACE2) and basigin (BSG); 2) severe acute respiratory syndrome coronavirus-2 receptor pathways ACE2/transmembrane serine protease 2 and BSG/peptidylprolyl isomerase B(A) polarize to lung/epithelium and vessel/endothelium, respectively; 3) expression of host genes is relatively stable with age; and 4) notable exceptions are ACE2, which decreases with age in some tissues, and BSG, which increases with age in endothelial cells, suggesting that BSG expression in the vasculature may explain the heightened risk for severe disease with age. Elsevier 2020-10-09 /pmc/articles/PMC7546186/ /pubmed/33073064 http://dx.doi.org/10.1016/j.jacbts.2020.09.010 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preclinical Research
Ahmetaj-Shala, Blerina
Vaja, Ricky
Atanur, Santosh S.
George, Peter M.
Kirkby, Nicholas S.
Mitchell, Jane A.
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title_full Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title_fullStr Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title_full_unstemmed Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title_short Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
title_sort cardiorenal tissues express sars-cov-2 entry genes and basigin (bsg/cd147) increases with age in endothelial cells
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546186/
https://www.ncbi.nlm.nih.gov/pubmed/33073064
http://dx.doi.org/10.1016/j.jacbts.2020.09.010
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