Cargando…
A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to ac...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546241/ https://www.ncbi.nlm.nih.gov/pubmed/33083136 http://dx.doi.org/10.7717/peerj.10079 |
_version_ | 1783592191036227584 |
---|---|
author | Chen, Jingbo Li, Gen Chen, Mingsheng Jin, Gui Zhao, Shuanglin Bai, Zelin Yang, Jun Liang, Huayou Xu, Jia Sun, Jian Qin, Mingxin |
author_facet | Chen, Jingbo Li, Gen Chen, Mingsheng Jin, Gui Zhao, Shuanglin Bai, Zelin Yang, Jun Liang, Huayou Xu, Jia Sun, Jian Qin, Mingxin |
author_sort | Chen, Jingbo |
collection | PubMed |
description | Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to achieve non-invasive continuous monitoring of CE. However, most existing MIPS sensors are made of hard materials which makes it difficult to accurately retrieve CE information. In this article, we designed a conformal two-coil structure and a single-coil structure, and studied their sensitivity map using finite element method (FEM). After that, the conformal MIPS sensor that is preferable for local CE monitoring was fabricated by flexible printed circuit (FPC). Next, physical experiments were conducted to investigate its performance on different levels of simulated CE solution volume, measurement distance, and bending. Subsequently, 14 rabbits were chosen to establish CE model and another three rabbits were selected as controls. The 24-hour MIPS real-time monitoring experiments was carried out to verify that the feasibility. Results showed a gentler attenuation trend of the conformal two-coil structure, compared with the single-coil structure. In addition, the novel flexible conformal MIPS sensor has a characteristic of being robust to bending according to the physical experiments. The results of animal experiments showed that the sensor can be used for CE monitoring. It can be concluded that this flexible conformal MIPS sensor is desirable for local focusing measurement of CE and subsequent multidimensional information extraction for predicting model. Also, it enables a much more comfortable environment for long-time bedside monitoring. |
format | Online Article Text |
id | pubmed-7546241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75462412020-10-19 A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction Chen, Jingbo Li, Gen Chen, Mingsheng Jin, Gui Zhao, Shuanglin Bai, Zelin Yang, Jun Liang, Huayou Xu, Jia Sun, Jian Qin, Mingxin PeerJ Bioengineering Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to achieve non-invasive continuous monitoring of CE. However, most existing MIPS sensors are made of hard materials which makes it difficult to accurately retrieve CE information. In this article, we designed a conformal two-coil structure and a single-coil structure, and studied their sensitivity map using finite element method (FEM). After that, the conformal MIPS sensor that is preferable for local CE monitoring was fabricated by flexible printed circuit (FPC). Next, physical experiments were conducted to investigate its performance on different levels of simulated CE solution volume, measurement distance, and bending. Subsequently, 14 rabbits were chosen to establish CE model and another three rabbits were selected as controls. The 24-hour MIPS real-time monitoring experiments was carried out to verify that the feasibility. Results showed a gentler attenuation trend of the conformal two-coil structure, compared with the single-coil structure. In addition, the novel flexible conformal MIPS sensor has a characteristic of being robust to bending according to the physical experiments. The results of animal experiments showed that the sensor can be used for CE monitoring. It can be concluded that this flexible conformal MIPS sensor is desirable for local focusing measurement of CE and subsequent multidimensional information extraction for predicting model. Also, it enables a much more comfortable environment for long-time bedside monitoring. PeerJ Inc. 2020-10-06 /pmc/articles/PMC7546241/ /pubmed/33083136 http://dx.doi.org/10.7717/peerj.10079 Text en ©2020 Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Bioengineering Chen, Jingbo Li, Gen Chen, Mingsheng Jin, Gui Zhao, Shuanglin Bai, Zelin Yang, Jun Liang, Huayou Xu, Jia Sun, Jian Qin, Mingxin A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title | A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title_full | A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title_fullStr | A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title_full_unstemmed | A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title_short | A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
title_sort | noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction |
topic | Bioengineering |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546241/ https://www.ncbi.nlm.nih.gov/pubmed/33083136 http://dx.doi.org/10.7717/peerj.10079 |
work_keys_str_mv | AT chenjingbo anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT ligen anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT chenmingsheng anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT jingui anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT zhaoshuanglin anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT baizelin anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT yangjun anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT lianghuayou anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT xujia anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT sunjian anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT qinmingxin anoninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT chenjingbo noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT ligen noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT chenmingsheng noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT jingui noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT zhaoshuanglin noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT baizelin noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT yangjun noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT lianghuayou noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT xujia noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT sunjian noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction AT qinmingxin noninvasiveflexibleconformalsensorforaccuraterealtimemonitoringoflocalcerebraledemabasedonelectromagneticinduction |