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A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction

Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to ac...

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Autores principales: Chen, Jingbo, Li, Gen, Chen, Mingsheng, Jin, Gui, Zhao, Shuanglin, Bai, Zelin, Yang, Jun, Liang, Huayou, Xu, Jia, Sun, Jian, Qin, Mingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546241/
https://www.ncbi.nlm.nih.gov/pubmed/33083136
http://dx.doi.org/10.7717/peerj.10079
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author Chen, Jingbo
Li, Gen
Chen, Mingsheng
Jin, Gui
Zhao, Shuanglin
Bai, Zelin
Yang, Jun
Liang, Huayou
Xu, Jia
Sun, Jian
Qin, Mingxin
author_facet Chen, Jingbo
Li, Gen
Chen, Mingsheng
Jin, Gui
Zhao, Shuanglin
Bai, Zelin
Yang, Jun
Liang, Huayou
Xu, Jia
Sun, Jian
Qin, Mingxin
author_sort Chen, Jingbo
collection PubMed
description Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to achieve non-invasive continuous monitoring of CE. However, most existing MIPS sensors are made of hard materials which makes it difficult to accurately retrieve CE information. In this article, we designed a conformal two-coil structure and a single-coil structure, and studied their sensitivity map using finite element method (FEM). After that, the conformal MIPS sensor that is preferable for local CE monitoring was fabricated by flexible printed circuit (FPC). Next, physical experiments were conducted to investigate its performance on different levels of simulated CE solution volume, measurement distance, and bending. Subsequently, 14 rabbits were chosen to establish CE model and another three rabbits were selected as controls. The 24-hour MIPS real-time monitoring experiments was carried out to verify that the feasibility. Results showed a gentler attenuation trend of the conformal two-coil structure, compared with the single-coil structure. In addition, the novel flexible conformal MIPS sensor has a characteristic of being robust to bending according to the physical experiments. The results of animal experiments showed that the sensor can be used for CE monitoring. It can be concluded that this flexible conformal MIPS sensor is desirable for local focusing measurement of CE and subsequent multidimensional information extraction for predicting model. Also, it enables a much more comfortable environment for long-time bedside monitoring.
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spelling pubmed-75462412020-10-19 A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction Chen, Jingbo Li, Gen Chen, Mingsheng Jin, Gui Zhao, Shuanglin Bai, Zelin Yang, Jun Liang, Huayou Xu, Jia Sun, Jian Qin, Mingxin PeerJ Bioengineering Cerebral edema (CE) is a non-specific pathological swelling of the brain secondary to any type of neurological injury. The real-time monitoring of focal CE mostly found in early stage is of great significance to reduce mortality and disability. Magnetic Induction Phase Shift (MIPS) is expected to achieve non-invasive continuous monitoring of CE. However, most existing MIPS sensors are made of hard materials which makes it difficult to accurately retrieve CE information. In this article, we designed a conformal two-coil structure and a single-coil structure, and studied their sensitivity map using finite element method (FEM). After that, the conformal MIPS sensor that is preferable for local CE monitoring was fabricated by flexible printed circuit (FPC). Next, physical experiments were conducted to investigate its performance on different levels of simulated CE solution volume, measurement distance, and bending. Subsequently, 14 rabbits were chosen to establish CE model and another three rabbits were selected as controls. The 24-hour MIPS real-time monitoring experiments was carried out to verify that the feasibility. Results showed a gentler attenuation trend of the conformal two-coil structure, compared with the single-coil structure. In addition, the novel flexible conformal MIPS sensor has a characteristic of being robust to bending according to the physical experiments. The results of animal experiments showed that the sensor can be used for CE monitoring. It can be concluded that this flexible conformal MIPS sensor is desirable for local focusing measurement of CE and subsequent multidimensional information extraction for predicting model. Also, it enables a much more comfortable environment for long-time bedside monitoring. PeerJ Inc. 2020-10-06 /pmc/articles/PMC7546241/ /pubmed/33083136 http://dx.doi.org/10.7717/peerj.10079 Text en ©2020 Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioengineering
Chen, Jingbo
Li, Gen
Chen, Mingsheng
Jin, Gui
Zhao, Shuanglin
Bai, Zelin
Yang, Jun
Liang, Huayou
Xu, Jia
Sun, Jian
Qin, Mingxin
A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title_full A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title_fullStr A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title_full_unstemmed A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title_short A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
title_sort noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction
topic Bioengineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546241/
https://www.ncbi.nlm.nih.gov/pubmed/33083136
http://dx.doi.org/10.7717/peerj.10079
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