Cargando…

Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis

CONTEXT: Few studies have been done for correlating asthma severity, IgE level, and spirometry results with high-resolution computed tomographic (HRCT) findings in allergic bronchopulmonary aspergillosis (ABPA). AIMS: This prospective observational study was conducted to correlate asthma severity, I...

Descripción completa

Detalles Bibliográficos
Autores principales: Neyaz, Zafar, Hashim, Zia, Kumar, Sunil, Nath, Alok, Khan, Ajmal, Mohindro, Namita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546303/
https://www.ncbi.nlm.nih.gov/pubmed/33100683
http://dx.doi.org/10.4103/ijri.IJRI_443_19
_version_ 1783592204557615104
author Neyaz, Zafar
Hashim, Zia
Kumar, Sunil
Nath, Alok
Khan, Ajmal
Mohindro, Namita
author_facet Neyaz, Zafar
Hashim, Zia
Kumar, Sunil
Nath, Alok
Khan, Ajmal
Mohindro, Namita
author_sort Neyaz, Zafar
collection PubMed
description CONTEXT: Few studies have been done for correlating asthma severity, IgE level, and spirometry results with high-resolution computed tomographic (HRCT) findings in allergic bronchopulmonary aspergillosis (ABPA). AIMS: This prospective observational study was conducted to correlate asthma severity, IgE level, and spirometry results with HRCT findings in ABPA. SETTINGS AND DESIGN: Prospective observational. SUBJECTS AND METHODS: Fifty consecutive adult patients with asthma and positive specific IgE (>0.35 kUA/L) to Aspergillus fumigatus were recruited from October 2015 to July 2017. Asthma severity, IgE levels, and spirometry results were correlated with HRCT score, bronchiectasis score, air trapping segments, and low-attenuation lung volume on inspiratory CT and expiratory CT. STATISTICAL ANALYSIS USED: One way ANOVA, Spearman's correlation coefficients. RESULTS: Asthma severity showed a significant positive correlation with HRCT score and bronchiectasis score. MEF pre and postbronchodilator values showed a significant negative correlation with HRCT score, bronchiectasis score, and percentage expiratory volumes -851 to -950 HU voxels. FEV1 prebronchodilator value showed a significant negative correlation with percentage expiratory volume -851 to -950 HU voxels and percentage expiratory volume -851 to -1024 HU voxels. Specific IgE antibody level showed a significant positive correlation with bronchiectasis score. CONCLUSIONS: Asthma severity, specific IgE level, and MEF values showed a good correlation with HRCT findings. The restrictive pattern is common on spirometry in patients of ABPA. In addition to central bronchiectasis, peripheral bronchial and small airway involvement was an important finding in ABPA. Expiratory HRCT may reveal air trapping in patients having no abnormality on inspiratory CT.
format Online
Article
Text
id pubmed-7546303
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-75463032020-10-22 Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis Neyaz, Zafar Hashim, Zia Kumar, Sunil Nath, Alok Khan, Ajmal Mohindro, Namita Indian J Radiol Imaging Thoracic Imaging CONTEXT: Few studies have been done for correlating asthma severity, IgE level, and spirometry results with high-resolution computed tomographic (HRCT) findings in allergic bronchopulmonary aspergillosis (ABPA). AIMS: This prospective observational study was conducted to correlate asthma severity, IgE level, and spirometry results with HRCT findings in ABPA. SETTINGS AND DESIGN: Prospective observational. SUBJECTS AND METHODS: Fifty consecutive adult patients with asthma and positive specific IgE (>0.35 kUA/L) to Aspergillus fumigatus were recruited from October 2015 to July 2017. Asthma severity, IgE levels, and spirometry results were correlated with HRCT score, bronchiectasis score, air trapping segments, and low-attenuation lung volume on inspiratory CT and expiratory CT. STATISTICAL ANALYSIS USED: One way ANOVA, Spearman's correlation coefficients. RESULTS: Asthma severity showed a significant positive correlation with HRCT score and bronchiectasis score. MEF pre and postbronchodilator values showed a significant negative correlation with HRCT score, bronchiectasis score, and percentage expiratory volumes -851 to -950 HU voxels. FEV1 prebronchodilator value showed a significant negative correlation with percentage expiratory volume -851 to -950 HU voxels and percentage expiratory volume -851 to -1024 HU voxels. Specific IgE antibody level showed a significant positive correlation with bronchiectasis score. CONCLUSIONS: Asthma severity, specific IgE level, and MEF values showed a good correlation with HRCT findings. The restrictive pattern is common on spirometry in patients of ABPA. In addition to central bronchiectasis, peripheral bronchial and small airway involvement was an important finding in ABPA. Expiratory HRCT may reveal air trapping in patients having no abnormality on inspiratory CT. Wolters Kluwer - Medknow 2020 2020-07-13 /pmc/articles/PMC7546303/ /pubmed/33100683 http://dx.doi.org/10.4103/ijri.IJRI_443_19 Text en Copyright: © 2020 Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Thoracic Imaging
Neyaz, Zafar
Hashim, Zia
Kumar, Sunil
Nath, Alok
Khan, Ajmal
Mohindro, Namita
Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title_full Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title_fullStr Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title_full_unstemmed Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title_short Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis
title_sort correlation of asthma severity, ige level, and spirometry results with hrct findings in allergic bronchopulmonary aspergillosis
topic Thoracic Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546303/
https://www.ncbi.nlm.nih.gov/pubmed/33100683
http://dx.doi.org/10.4103/ijri.IJRI_443_19
work_keys_str_mv AT neyazzafar correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis
AT hashimzia correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis
AT kumarsunil correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis
AT nathalok correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis
AT khanajmal correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis
AT mohindronamita correlationofasthmaseverityigelevelandspirometryresultswithhrctfindingsinallergicbronchopulmonaryaspergillosis