IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small....

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Detalles Bibliográficos
Autores principales: Barlow, Nicholas, Thompson, Philip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546331/
https://www.ncbi.nlm.nih.gov/pubmed/33101040
http://dx.doi.org/10.3389/fphar.2020.585930
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author Barlow, Nicholas
Thompson, Philip E.
author_facet Barlow, Nicholas
Thompson, Philip E.
author_sort Barlow, Nicholas
collection PubMed
description The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors.
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spelling pubmed-75463312020-10-22 IRAP Inhibitors: M1-Aminopeptidase Family Inspiration Barlow, Nicholas Thompson, Philip E. Front Pharmacol Pharmacology The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7546331/ /pubmed/33101040 http://dx.doi.org/10.3389/fphar.2020.585930 Text en Copyright © 2020 Barlow and Thompson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Barlow, Nicholas
Thompson, Philip E.
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title_full IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title_fullStr IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title_full_unstemmed IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title_short IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
title_sort irap inhibitors: m1-aminopeptidase family inspiration
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546331/
https://www.ncbi.nlm.nih.gov/pubmed/33101040
http://dx.doi.org/10.3389/fphar.2020.585930
work_keys_str_mv AT barlownicholas irapinhibitorsm1aminopeptidasefamilyinspiration
AT thompsonphilipe irapinhibitorsm1aminopeptidasefamilyinspiration

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