Programmed Adult Kidney Disease: Importance of Fetal Environment

The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay...

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Autores principales: Argeri, Rogério, Thomazini, Fernanda, Lichtenecker, Débora Conte Kimura, Thieme, Karina, do Carmo Franco, Maria, Gomes, Guiomar Nascimento
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546361/
https://www.ncbi.nlm.nih.gov/pubmed/33101064
http://dx.doi.org/10.3389/fphys.2020.586290
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author Argeri, Rogério
Thomazini, Fernanda
Lichtenecker, Débora Conte Kimura
Thieme, Karina
do Carmo Franco, Maria
Gomes, Guiomar Nascimento
author_facet Argeri, Rogério
Thomazini, Fernanda
Lichtenecker, Débora Conte Kimura
Thieme, Karina
do Carmo Franco, Maria
Gomes, Guiomar Nascimento
author_sort Argeri, Rogério
collection PubMed
description The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce epigenetic changes and lead to alterations in the expression of renal phenotype. In this review, we have explored the renal development and its functions, while focusing on the epigenetic findings and functional aspects of the renin-angiotensin system and its components.
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spelling pubmed-75463612020-10-22 Programmed Adult Kidney Disease: Importance of Fetal Environment Argeri, Rogério Thomazini, Fernanda Lichtenecker, Débora Conte Kimura Thieme, Karina do Carmo Franco, Maria Gomes, Guiomar Nascimento Front Physiol Physiology The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce epigenetic changes and lead to alterations in the expression of renal phenotype. In this review, we have explored the renal development and its functions, while focusing on the epigenetic findings and functional aspects of the renin-angiotensin system and its components. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7546361/ /pubmed/33101064 http://dx.doi.org/10.3389/fphys.2020.586290 Text en Copyright © 2020 Argeri, Thomazini, Lichtenecker, Thieme, Franco and Gomes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Argeri, Rogério
Thomazini, Fernanda
Lichtenecker, Débora Conte Kimura
Thieme, Karina
do Carmo Franco, Maria
Gomes, Guiomar Nascimento
Programmed Adult Kidney Disease: Importance of Fetal Environment
title Programmed Adult Kidney Disease: Importance of Fetal Environment
title_full Programmed Adult Kidney Disease: Importance of Fetal Environment
title_fullStr Programmed Adult Kidney Disease: Importance of Fetal Environment
title_full_unstemmed Programmed Adult Kidney Disease: Importance of Fetal Environment
title_short Programmed Adult Kidney Disease: Importance of Fetal Environment
title_sort programmed adult kidney disease: importance of fetal environment
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546361/
https://www.ncbi.nlm.nih.gov/pubmed/33101064
http://dx.doi.org/10.3389/fphys.2020.586290
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