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PEGylation of Deferoxamine for Improving the Stability, Cytotoxicity, and Iron-Overload in an Experimental Stroke Model in Rats

Deferoxamine (DFO) is a widely used drug for the treatment of iron-overload-related diseases in the clinic. However, its inherent shortcomings, such as a short plasma half-life and cytotoxicity, need to be addressed to widen its clinical utility. In this study, PEGylated DFO was first synthesized, a...

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Detalles Bibliográficos
Autores principales:	Xu, Jiake, Sun, Tong, Zhong, Rui, You, Chao, Tian, Meng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546414/ https://www.ncbi.nlm.nih.gov/pubmed/33102469 http://dx.doi.org/10.3389/fbioe.2020.592294

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