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Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness
Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (DOC) has become a more commonly occurring clinical issue. One recently developed intervention option has been non-invasive transcranial direct current stimulation. This dichotomy of patient responders may...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546425/ https://www.ncbi.nlm.nih.gov/pubmed/33100977 http://dx.doi.org/10.3389/fnsys.2020.00062 |
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author | Mensen, Armand Bodart, Olivier Thibaut, Aurore Wannez, Sarah Annen, Jitka Laureys, Steven Gosseries, Olivia |
author_facet | Mensen, Armand Bodart, Olivier Thibaut, Aurore Wannez, Sarah Annen, Jitka Laureys, Steven Gosseries, Olivia |
author_sort | Mensen, Armand |
collection | PubMed |
description | Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (DOC) has become a more commonly occurring clinical issue. One recently developed intervention option has been non-invasive transcranial direct current stimulation. This dichotomy of patient responders may be better understood by investigating the mechanism behind the transcranial direct current stimulation (tDCS) intervention. The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has been an important diagnostic tool in DOC patients. We therefore examined the neural response using TMS-EEG both before and after tDCS in seven DOC patients (four diagnosed as in a minimally conscious state and three with unresponsive wakefulness syndrome). tDCS was applied over the dorsolateral prefrontal cortex, while TMS pulses were applied to the premotor cortex. None of the seven patients showed relevant behavioral change after tDCS. We did, however, find that the overall evoked slow activity was reduced following tDCS intervention. We also found a positive correlation between the strength of the slow activity and the amount of high-frequency suppression. However, there was no significant pre-post tDCS difference in high frequencies. In the resting-state EEG, we observed that both the incidence of slow waves and the positive slope of the wave were affected by tDCS. Taken together, these results suggest that the tDCS intervention can reduce the slow-wave activity component of bistability, but this may not directly affect high-frequency activity. We hypothesize that while reduced slow activity may be necessary for the recovery of neural function, especially consciousness, this alone is insufficient. |
format | Online Article Text |
id | pubmed-7546425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75464252020-10-22 Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness Mensen, Armand Bodart, Olivier Thibaut, Aurore Wannez, Sarah Annen, Jitka Laureys, Steven Gosseries, Olivia Front Syst Neurosci Neuroscience Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (DOC) has become a more commonly occurring clinical issue. One recently developed intervention option has been non-invasive transcranial direct current stimulation. This dichotomy of patient responders may be better understood by investigating the mechanism behind the transcranial direct current stimulation (tDCS) intervention. The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has been an important diagnostic tool in DOC patients. We therefore examined the neural response using TMS-EEG both before and after tDCS in seven DOC patients (four diagnosed as in a minimally conscious state and three with unresponsive wakefulness syndrome). tDCS was applied over the dorsolateral prefrontal cortex, while TMS pulses were applied to the premotor cortex. None of the seven patients showed relevant behavioral change after tDCS. We did, however, find that the overall evoked slow activity was reduced following tDCS intervention. We also found a positive correlation between the strength of the slow activity and the amount of high-frequency suppression. However, there was no significant pre-post tDCS difference in high frequencies. In the resting-state EEG, we observed that both the incidence of slow waves and the positive slope of the wave were affected by tDCS. Taken together, these results suggest that the tDCS intervention can reduce the slow-wave activity component of bistability, but this may not directly affect high-frequency activity. We hypothesize that while reduced slow activity may be necessary for the recovery of neural function, especially consciousness, this alone is insufficient. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7546425/ /pubmed/33100977 http://dx.doi.org/10.3389/fnsys.2020.00062 Text en Copyright © 2020 Mensen, Bodart, Thibaut, Wannez, Annen, Laureys and Gosseries. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Mensen, Armand Bodart, Olivier Thibaut, Aurore Wannez, Sarah Annen, Jitka Laureys, Steven Gosseries, Olivia Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title | Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title_full | Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title_fullStr | Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title_full_unstemmed | Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title_short | Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness |
title_sort | decreased evoked slow-activity after tdcs in disorders of consciousness |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546425/ https://www.ncbi.nlm.nih.gov/pubmed/33100977 http://dx.doi.org/10.3389/fnsys.2020.00062 |
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