Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data

We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and impute missing values. Using synthetic and published single-cell CpG datasets, we show that Epiclomal outperforms non-probabilistic...

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Detalles Bibliográficos
Autores principales: P. E. de Souza, Camila, Andronescu, Mirela, Masud, Tehmina, Kabeer, Farhia, Biele, Justina, Laks, Emma, Lai, Daniel, Ye, Patricia, Brimhall, Jazmine, Wang, Beixi, Su, Edmund, Hui, Tony, Cao, Qi, Wong, Marcus, Moksa, Michelle, Moore, Richard A., Hirst, Martin, Aparicio, Samuel, Shah, Sohrab P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546467/
https://www.ncbi.nlm.nih.gov/pubmed/32966276
http://dx.doi.org/10.1371/journal.pcbi.1008270

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