Synthetic group A streptogramin antibiotics that overcome Vat resistance

Natural products serve as chemical blueprints for the majority of antibiotics in our clinical arsenal. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class(1). Virginiamyci...

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Detalles Bibliográficos
Autores principales: Li, Qi, Pellegrino, Jenna, Lee, D. John, Tran, Arthur A., Chaires, Hector A., Wang, Ruoxi, Park, Jesslyn E., Ji, Kaijie, Chow, David, Zhang, Na, Brilot, Axel F., Biel, Justin T., van Zundert, Gydo, Borrelli, Kenneth, Shinabarger, Dean, Wolfe, Cindy, Murray, Beverly, Jacobson, Matthew P., Mühle, Estelle, Chesneau, Olivier, Fraser, James S., Seiple, Ian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546582/
https://www.ncbi.nlm.nih.gov/pubmed/32968273
http://dx.doi.org/10.1038/s41586-020-2761-3

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