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Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease

Although mild elevations in liver enzymes are relatively common in thyrotoxicosis, acute liver failure (ALF) is an infrequent occurrence. Despite the emergence of liver transplantation as a viable treatment for ALF, survival rates continue to remain unsatisfactory, coupled with higher rates of posto...

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Autores principales: Hayat, Muhammad Hashim, Moazzam, Zorays, Ziogas, Ioannis A, Yousaf, Amman, Hayat, Maham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546597/
https://www.ncbi.nlm.nih.gov/pubmed/33052294
http://dx.doi.org/10.7759/cureus.10333
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author Hayat, Muhammad Hashim
Moazzam, Zorays
Ziogas, Ioannis A
Yousaf, Amman
Hayat, Maham
author_facet Hayat, Muhammad Hashim
Moazzam, Zorays
Ziogas, Ioannis A
Yousaf, Amman
Hayat, Maham
author_sort Hayat, Muhammad Hashim
collection PubMed
description Although mild elevations in liver enzymes are relatively common in thyrotoxicosis, acute liver failure (ALF) is an infrequent occurrence. Despite the emergence of liver transplantation as a viable treatment for ALF, survival rates continue to remain unsatisfactory, coupled with higher rates of postoperative complications and re-transplantation in this group. We present the disease course, management, and outcome of a patient with Graves’ disease who presented with ALF secondary to thyroid storm. Thyrotoxicosis should always be included in the differential diagnosis of ALF, as timely diagnosis and management are crucial in achieving survival.
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spelling pubmed-75465972020-10-12 Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease Hayat, Muhammad Hashim Moazzam, Zorays Ziogas, Ioannis A Yousaf, Amman Hayat, Maham Cureus Endocrinology/Diabetes/Metabolism Although mild elevations in liver enzymes are relatively common in thyrotoxicosis, acute liver failure (ALF) is an infrequent occurrence. Despite the emergence of liver transplantation as a viable treatment for ALF, survival rates continue to remain unsatisfactory, coupled with higher rates of postoperative complications and re-transplantation in this group. We present the disease course, management, and outcome of a patient with Graves’ disease who presented with ALF secondary to thyroid storm. Thyrotoxicosis should always be included in the differential diagnosis of ALF, as timely diagnosis and management are crucial in achieving survival. Cureus 2020-09-09 /pmc/articles/PMC7546597/ /pubmed/33052294 http://dx.doi.org/10.7759/cureus.10333 Text en Copyright © 2020, Hayat et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Hayat, Muhammad Hashim
Moazzam, Zorays
Ziogas, Ioannis A
Yousaf, Amman
Hayat, Maham
Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title_full Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title_fullStr Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title_full_unstemmed Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title_short Thyroid Storm Presenting as Acute Liver Failure in a Patient with Graves’ Disease
title_sort thyroid storm presenting as acute liver failure in a patient with graves’ disease
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546597/
https://www.ncbi.nlm.nih.gov/pubmed/33052294
http://dx.doi.org/10.7759/cureus.10333
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