Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells

Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unknown. Using functional genomics, we determine modifiers of l-asparaginase (ASNase) response and identify thiamine pyrophosphate kinase 1 as a metabolic dependency under AS...

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Detalles Bibliográficos
Autores principales: Guarecuco, Rohiverth, Williams, Robert T., Baudrier, Lou, La, Konnor, Passarelli, Maria C., Ekizoglu, Naz, Mestanoglu, Mert, Alwaseem, Hanan, Rostandy, Bety, Fidelin, Justine, Garcia-Bermudez, Javier, Molina, Henrik, Birsoy, Kıvanç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546708/
https://www.ncbi.nlm.nih.gov/pubmed/33036978
http://dx.doi.org/10.1126/sciadv.abc7120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546708/
https://www.ncbi.nlm.nih.gov/pubmed/33036978
http://dx.doi.org/10.1126/sciadv.abc7120

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