ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule

The development of drugs with rapid distribution in the kidney and long-term retention in the renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l-serine–modified chitosan (SC) was synthesized as a potential AKI kidney–targeting agent due to the native cationic...

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Detalles Bibliográficos
Autores principales: Liu, Di, Shu, Gaofeng, Jin, Feiyang, Qi, Jing, Xu, Xiaoling, Du, Yan, Yu, Hui, Wang, Jun, Sun, Mingchen, You, Yuchan, Zhu, Minxia, Chen, Meixuan, Zhu, Luwen, Shen, Qiying, Ying, Xiaoying, Lou, Xuefang, Jiang, Saiping, Du, Yongzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546709/
https://www.ncbi.nlm.nih.gov/pubmed/33036968
http://dx.doi.org/10.1126/sciadv.abb7422

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