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3D printed self-supporting elastomeric structures for multifunctional microfluidics

Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substr...

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Autores principales: Su, Ruitao, Wen, Jiaxuan, Su, Qun, Wiederoder, Michael S., Koester, Steven J., Uzarski, Joshua R., McAlpine, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546717/
https://www.ncbi.nlm.nih.gov/pubmed/33036980
http://dx.doi.org/10.1126/sciadv.abc9846
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author Su, Ruitao
Wen, Jiaxuan
Su, Qun
Wiederoder, Michael S.
Koester, Steven J.
Uzarski, Joshua R.
McAlpine, Michael C.
author_facet Su, Ruitao
Wen, Jiaxuan
Su, Qun
Wiederoder, Michael S.
Koester, Steven J.
Uzarski, Joshua R.
McAlpine, Michael C.
author_sort Su, Ruitao
collection PubMed
description Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substrates as well as improved automation for higher throughput. Current additive manufacturing methods, such as stereolithography and multi-jet printing, tend to contaminate substrates with uncured resins or supporting materials during printing. Here, we present a printing methodology based on precisely extruding viscoelastic inks into self-supporting microchannels and chambers without requiring sacrificial materials. We demonstrate that, in the submillimeter regime, the yield strength of the as-extruded silicone ink is sufficient to prevent creep within a certain angular range. Printing toolpaths are specifically designed to realize leakage-free connections between channels and chambers, T-shaped intersections, and overlapping channels. The self-supporting microfluidic structures enable the automatable fabrication of multifunctional devices, including multimaterial mixers, microfluidic-integrated sensors, automation components, and 3D microfluidics.
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spelling pubmed-75467172020-10-20 3D printed self-supporting elastomeric structures for multifunctional microfluidics Su, Ruitao Wen, Jiaxuan Su, Qun Wiederoder, Michael S. Koester, Steven J. Uzarski, Joshua R. McAlpine, Michael C. Sci Adv Research Articles Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substrates as well as improved automation for higher throughput. Current additive manufacturing methods, such as stereolithography and multi-jet printing, tend to contaminate substrates with uncured resins or supporting materials during printing. Here, we present a printing methodology based on precisely extruding viscoelastic inks into self-supporting microchannels and chambers without requiring sacrificial materials. We demonstrate that, in the submillimeter regime, the yield strength of the as-extruded silicone ink is sufficient to prevent creep within a certain angular range. Printing toolpaths are specifically designed to realize leakage-free connections between channels and chambers, T-shaped intersections, and overlapping channels. The self-supporting microfluidic structures enable the automatable fabrication of multifunctional devices, including multimaterial mixers, microfluidic-integrated sensors, automation components, and 3D microfluidics. American Association for the Advancement of Science 2020-10-09 /pmc/articles/PMC7546717/ /pubmed/33036980 http://dx.doi.org/10.1126/sciadv.abc9846 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Su, Ruitao
Wen, Jiaxuan
Su, Qun
Wiederoder, Michael S.
Koester, Steven J.
Uzarski, Joshua R.
McAlpine, Michael C.
3D printed self-supporting elastomeric structures for multifunctional microfluidics
title 3D printed self-supporting elastomeric structures for multifunctional microfluidics
title_full 3D printed self-supporting elastomeric structures for multifunctional microfluidics
title_fullStr 3D printed self-supporting elastomeric structures for multifunctional microfluidics
title_full_unstemmed 3D printed self-supporting elastomeric structures for multifunctional microfluidics
title_short 3D printed self-supporting elastomeric structures for multifunctional microfluidics
title_sort 3d printed self-supporting elastomeric structures for multifunctional microfluidics
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546717/
https://www.ncbi.nlm.nih.gov/pubmed/33036980
http://dx.doi.org/10.1126/sciadv.abc9846
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