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Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study

Objectives: To investigate neuroendocrine carcinoma (NEC) of the uterine cervix cases for MRI features and staging, as well as pathological correlations and survival. Results: FIGO was I in 42, II in 14, III in 1, and IV in 5 patients. T2-weighted MRI showed homogeneous slightly high signal intensit...

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Detalles Bibliográficos
Autores principales: Kitajima, Kazuhiro, Kihara, Takako, Kawanaka, Yusuke, Kido, Aki, Yoshida, Kotaro, Mizumoto, Yasunari, Tomiyama, Akiko, Okuda, Shigeo, Jinzaki, Masahiro, Kato, Fumi, Takahama, Junko, Takahata, Akiko, Fukukura, Yoshihiko, Nakamoto, Atsushi, Tsujikawa, Tetsuya, Munechika, Jiro, Ohgiya, Yoshimitstu, Kawai, Nobuyuki, Goshima, Satoshi, Ohya, Ayumi, Fujinaga, Yasunari, Fukunaga, Takeru, Fujii, Shinya, Tanabe, Masahiro, Ito, Katsuyoshi, Tsuboyama, Takahiro, Kanie, Yuichiro, Umeoka, Shigeaki, Ichikawa, Shintaro, Motosugi, Utaroh, Daido, Sayaka, Kido, Ayumu, Tamada, Tsutomu, Matsuki, Mitsuru, Yamashiro, Tsuneo, Yamakado, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546756/
https://www.ncbi.nlm.nih.gov/pubmed/33088427
http://dx.doi.org/10.18632/oncotarget.27613
Descripción
Sumario:Objectives: To investigate neuroendocrine carcinoma (NEC) of the uterine cervix cases for MRI features and staging, as well as pathological correlations and survival. Results: FIGO was I in 42, II in 14, III in 1, and IV in 5 patients. T2-weighted MRI showed homogeneous slightly high signal intensity and obvious restricted diffusion (ADC map, low intensity; DWI, high intensity) throughout the tumor in most cases, and mild enhancement in two-thirds. In 50 patients who underwent a radical hysterectomy and lymphadenectomy without neoadjuvant chemotherapy (NAC), intrapelvic T staging by MRI overall accuracy was 88.0% with reference to pathology staging, while patient-based sensitivity, specificity, and accuracy for metastatic pelvic lymph node detection was 38.5%, 100%, and 83.3%, respectively. During a mean follow-up period of 45.6 months (range 4.3–151.0 months), 28 patients (45.2%) experienced recurrence and 24 (38.7%) died. Three-year progression-free and overall survival rates for FIGO I, II, III, and IV were 64.3% and 80.9%, 50% and 64.3%, 0% and 0%, and 0% and 0%, respectively. Materials and Methods: Sixty-two patients with histologically surgery-proven uterine cervical NEC were enrolled. Twelve received NAC. Clinical data, pathological findings, and pretreatment pelvic MRI findings were retrospectively reviewed. Thirty-two tumors were pure NEC and 30 mixed with other histotypes. The NECs were small cell type (41), large cell type (18), or a mixture of both (3). Conclusions: Homogeneous lesion texture with obvious restricted diffusion throughout the tumor are features suggestive of cervical NEC. Our findings show that MRI is reliable for T staging of cervical NEC.