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Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis

Background: Gross strap muscle invasion (gSMI) in patients with differentiated thyroid cancer (DTC) was defined as high-risk recurrent group in the 2015 American Thyroid Association guidelines. However, controversy persists because several studies suggested gSMI had little effect on disease outcome....

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Autores principales: Zhang, Li, Liu, Jia, Wang, Peisong, Xue, Shuai, Li, Jie, Chen, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546766/
https://www.ncbi.nlm.nih.gov/pubmed/33102203
http://dx.doi.org/10.3389/fonc.2020.01687
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author Zhang, Li
Liu, Jia
Wang, Peisong
Xue, Shuai
Li, Jie
Chen, Guang
author_facet Zhang, Li
Liu, Jia
Wang, Peisong
Xue, Shuai
Li, Jie
Chen, Guang
author_sort Zhang, Li
collection PubMed
description Background: Gross strap muscle invasion (gSMI) in patients with differentiated thyroid cancer (DTC) was defined as high-risk recurrent group in the 2015 American Thyroid Association guidelines. However, controversy persists because several studies suggested gSMI had little effect on disease outcome. Herein, a systematic review and meta-analysis was conducted to investigate impact of gSMI on outcome of DTC. Methods: A systematic search of electronic databases (PubMed, EMBASE, Cochrane Library, and MEDLINE) for studies published until February 2020 was performed. Case-control studies and randomized controlled trials that studied the impact of gSMI on outcome of DTC were included. Results: Six studies (all retrospective studies) involving 13,639 patients met final inclusion criteria. Compared with no extrathyroidal extension (ETE), patients with gSMI were associated with increased risk of recurrence (P = 0.0004, OR, 1.46; 95% CI: 1.18–1.80) and lymph node metastasis (LNM) (P < 0.00001, OR 4.19; 95% CI: 2.53–6.96). For mortality (P = 0.34, OR 1.47; 95% CI: 0.67–3.25), 10 year disease-specific survival (P = 0.80, OR 0.91; 95% CI: 0.44–1.88), and distant metastasis (DM) (P = 0.21, OR 2.94; 95% CI: 0.54–15.93), there was no significant difference between gSMI and no ETE group. In contrast with maximal ETE(extension of the primary tumor to the trachea, esophagus, recurrent laryngeal nerve, larynx, subcutaneous soft tissue, skin, internal jugular vein, or carotid artery), patients with gSMI were associated with decreased risk of recurrence (P < 0.0001, OR, 0.58; 95% CI: 0.44–0.76), mortality (P = 0.0003, OR 0.20; 95% CI: 0.08–0.48), LNM (P = 0.0003, OR 0.64; 95% CI: 0.50–0.81), and DM (P = 0.0009, OR 0.28; 95% CI: 0.13–0.59). Conclusions : DTC patients with gSMI had a higher risk of recurrence and LNM than those without ETE. However, in contrast with maximal ETE, a much better prognosis was observed in DTC patients with only gSMI.
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spelling pubmed-75467662020-10-22 Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis Zhang, Li Liu, Jia Wang, Peisong Xue, Shuai Li, Jie Chen, Guang Front Oncol Oncology Background: Gross strap muscle invasion (gSMI) in patients with differentiated thyroid cancer (DTC) was defined as high-risk recurrent group in the 2015 American Thyroid Association guidelines. However, controversy persists because several studies suggested gSMI had little effect on disease outcome. Herein, a systematic review and meta-analysis was conducted to investigate impact of gSMI on outcome of DTC. Methods: A systematic search of electronic databases (PubMed, EMBASE, Cochrane Library, and MEDLINE) for studies published until February 2020 was performed. Case-control studies and randomized controlled trials that studied the impact of gSMI on outcome of DTC were included. Results: Six studies (all retrospective studies) involving 13,639 patients met final inclusion criteria. Compared with no extrathyroidal extension (ETE), patients with gSMI were associated with increased risk of recurrence (P = 0.0004, OR, 1.46; 95% CI: 1.18–1.80) and lymph node metastasis (LNM) (P < 0.00001, OR 4.19; 95% CI: 2.53–6.96). For mortality (P = 0.34, OR 1.47; 95% CI: 0.67–3.25), 10 year disease-specific survival (P = 0.80, OR 0.91; 95% CI: 0.44–1.88), and distant metastasis (DM) (P = 0.21, OR 2.94; 95% CI: 0.54–15.93), there was no significant difference between gSMI and no ETE group. In contrast with maximal ETE(extension of the primary tumor to the trachea, esophagus, recurrent laryngeal nerve, larynx, subcutaneous soft tissue, skin, internal jugular vein, or carotid artery), patients with gSMI were associated with decreased risk of recurrence (P < 0.0001, OR, 0.58; 95% CI: 0.44–0.76), mortality (P = 0.0003, OR 0.20; 95% CI: 0.08–0.48), LNM (P = 0.0003, OR 0.64; 95% CI: 0.50–0.81), and DM (P = 0.0009, OR 0.28; 95% CI: 0.13–0.59). Conclusions : DTC patients with gSMI had a higher risk of recurrence and LNM than those without ETE. However, in contrast with maximal ETE, a much better prognosis was observed in DTC patients with only gSMI. Frontiers Media S.A. 2020-09-25 /pmc/articles/PMC7546766/ /pubmed/33102203 http://dx.doi.org/10.3389/fonc.2020.01687 Text en Copyright © 2020 Zhang, Liu, Wang, Xue, Li and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Li
Liu, Jia
Wang, Peisong
Xue, Shuai
Li, Jie
Chen, Guang
Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title_full Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title_fullStr Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title_full_unstemmed Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title_short Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis
title_sort impact of gross strap muscle invasion on outcome of differentiated thyroid cancer: systematic review and meta-analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546766/
https://www.ncbi.nlm.nih.gov/pubmed/33102203
http://dx.doi.org/10.3389/fonc.2020.01687
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