Cargando…
Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS
Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of motor cortex gliomas on the cerebral white matter fiber bundle skeleton. The motor cortex glioma group included 21 patients, and the control group comprised 14 healthy volunteers. Both groups underwent magnet...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547011/ https://www.ncbi.nlm.nih.gov/pubmed/33037275 http://dx.doi.org/10.1038/s41598-020-73746-1 |
_version_ | 1783592342971744256 |
---|---|
author | Wang, Xiangdong Zhou, Chunyao Wang, Lei Wang, Yinyan Jiang, Tao |
author_facet | Wang, Xiangdong Zhou, Chunyao Wang, Lei Wang, Yinyan Jiang, Tao |
author_sort | Wang, Xiangdong |
collection | PubMed |
description | Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of motor cortex gliomas on the cerebral white matter fiber bundle skeleton. The motor cortex glioma group included 21 patients, and the control group comprised 14 healthy volunteers. Both groups underwent magnetic resonance imaging-based 3.0 T diffusion tensor imaging. We used tract-based spatial statistics to analyze the characteristics of white matter fiber bundles. The left and right motor cortex glioma groups were analyzed separately from the control group. Results were statistically corrected by the family-wise error rate. Compared with the controls, patients with left motor cortex gliomas exhibited significantly reduced fractional anisotropy and an increased radial diffusivity in the corpus callosum. The alterations in mean diffusivity (MD) and the axial diffusivity (AD) were widely distributed throughout the brain. Furthermore, atlas-based analysis showed elevated MD and AD in the contralateral superior fronto-occipital fasciculus. Motor cortex gliomas significantly affect white matter fiber microstructure proximal to the tumor. The range of affected white matter fibers may extend beyond the tumor-affected area. These changes are primarily related to early stage tumor invasion. |
format | Online Article Text |
id | pubmed-7547011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75470112020-10-14 Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS Wang, Xiangdong Zhou, Chunyao Wang, Lei Wang, Yinyan Jiang, Tao Sci Rep Article Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of motor cortex gliomas on the cerebral white matter fiber bundle skeleton. The motor cortex glioma group included 21 patients, and the control group comprised 14 healthy volunteers. Both groups underwent magnetic resonance imaging-based 3.0 T diffusion tensor imaging. We used tract-based spatial statistics to analyze the characteristics of white matter fiber bundles. The left and right motor cortex glioma groups were analyzed separately from the control group. Results were statistically corrected by the family-wise error rate. Compared with the controls, patients with left motor cortex gliomas exhibited significantly reduced fractional anisotropy and an increased radial diffusivity in the corpus callosum. The alterations in mean diffusivity (MD) and the axial diffusivity (AD) were widely distributed throughout the brain. Furthermore, atlas-based analysis showed elevated MD and AD in the contralateral superior fronto-occipital fasciculus. Motor cortex gliomas significantly affect white matter fiber microstructure proximal to the tumor. The range of affected white matter fibers may extend beyond the tumor-affected area. These changes are primarily related to early stage tumor invasion. Nature Publishing Group UK 2020-10-09 /pmc/articles/PMC7547011/ /pubmed/33037275 http://dx.doi.org/10.1038/s41598-020-73746-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Xiangdong Zhou, Chunyao Wang, Lei Wang, Yinyan Jiang, Tao Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title | Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title_full | Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title_fullStr | Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title_full_unstemmed | Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title_short | Motor cortex gliomas induces microstructural changes of large fiber tracts revealed by TBSS |
title_sort | motor cortex gliomas induces microstructural changes of large fiber tracts revealed by tbss |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547011/ https://www.ncbi.nlm.nih.gov/pubmed/33037275 http://dx.doi.org/10.1038/s41598-020-73746-1 |
work_keys_str_mv | AT wangxiangdong motorcortexgliomasinducesmicrostructuralchangesoflargefibertractsrevealedbytbss AT zhouchunyao motorcortexgliomasinducesmicrostructuralchangesoflargefibertractsrevealedbytbss AT wanglei motorcortexgliomasinducesmicrostructuralchangesoflargefibertractsrevealedbytbss AT wangyinyan motorcortexgliomasinducesmicrostructuralchangesoflargefibertractsrevealedbytbss AT jiangtao motorcortexgliomasinducesmicrostructuralchangesoflargefibertractsrevealedbytbss |