The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress

Exposure of gastric epithelial cells to the bacterial carcinogen Helicobacter pylori causes DNA double strand breaks. Here, we show that H. pylori-induced DNA damage occurs co-transcriptionally in S-phase cells that activate NF-κB signaling upon innate immune recognition of the lipopolysaccharide bi...

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Detalles Bibliográficos
Autores principales: Bauer, Michael, Nascakova, Zuzana, Mihai, Anca-Irina, Cheng, Phil F., Levesque, Mitchell P., Lampart, Simon, Hurwitz, Robert, Pfannkuch, Lennart, Dobrovolna, Jana, Jacobs, Melanie, Bartfeld, Sina, Dohlman, Anders, Shen, Xiling, Gall, Alevtina A., Salama, Nina R., Töpfer, Antonia, Weber, Achim, Meyer, Thomas F., Janscak, Pavel, Müller, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547021/
https://www.ncbi.nlm.nih.gov/pubmed/33037203
http://dx.doi.org/10.1038/s41467-020-18857-z

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