Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

Skeletal muscle fibers are large syncytia but it is currently unknown whether gene expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq and snATAC-seq that slow, fast, myotendinous and neuromuscular junction myonuclei each have different transcriptional programs,...

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Detalles Bibliográficos
Autores principales: Dos Santos, Matthieu, Backer, Stéphanie, Saintpierre, Benjamin, Izac, Brigitte, Andrieu, Muriel, Letourneur, Franck, Relaix, Frederic, Sotiropoulos, Athanassia, Maire, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547110/
https://www.ncbi.nlm.nih.gov/pubmed/33037211
http://dx.doi.org/10.1038/s41467-020-18789-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547110/
https://www.ncbi.nlm.nih.gov/pubmed/33037211
http://dx.doi.org/10.1038/s41467-020-18789-8

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