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Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Skeletal muscle fibers are large syncytia but it is currently unknown whether gene expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq and snATAC-seq that slow, fast, myotendinous and neuromuscular junction myonuclei each have different transcriptional programs,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547110/ https://www.ncbi.nlm.nih.gov/pubmed/33037211 http://dx.doi.org/10.1038/s41467-020-18789-8 |