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Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial

RATIONALE: Excess mucus plays a key role in COPD pathogenesis. Cigarette smoke-induced cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may contribute to disease pathogenesis by depleting airway surface liquid and reducing mucociliary transport; these defects can be corrected i...

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Detalles Bibliográficos
Autores principales:	Rowe, Steven M, Jones, Ieuan, Dransfield, Mark T, Haque, Nazmul, Gleason, Stephen, Hayes, Katy A, Kulmatycki, Kenneth, Yates, Denise P, Danahay, Henry, Gosling, Martin, Rowlands, David J, Grant, Sarah S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Clinical Trial Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547289/ https://www.ncbi.nlm.nih.gov/pubmed/33116455 http://dx.doi.org/10.2147/COPD.S257474

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