A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful

A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) me...

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Autores principales: Hirouchi, Takatomo, Ota, Shinichiro, Mashima, Dai, Boku, Ryuichi, Yoshida, Yuto, Iwata, Koki, Shinada, Kanako, Matsumoto, Takashi, Morikawa, Miwa, Sato, Takashi, Shinoda, Masahiro, Kamachi, Kenichi, Shinkai, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547611/
https://www.ncbi.nlm.nih.gov/pubmed/33268271
http://dx.doi.org/10.1016/j.jiac.2020.10.011
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author Hirouchi, Takatomo
Ota, Shinichiro
Mashima, Dai
Boku, Ryuichi
Yoshida, Yuto
Iwata, Koki
Shinada, Kanako
Matsumoto, Takashi
Morikawa, Miwa
Sato, Takashi
Shinoda, Masahiro
Kamachi, Kenichi
Shinkai, Masaharu
author_facet Hirouchi, Takatomo
Ota, Shinichiro
Mashima, Dai
Boku, Ryuichi
Yoshida, Yuto
Iwata, Koki
Shinada, Kanako
Matsumoto, Takashi
Morikawa, Miwa
Sato, Takashi
Shinoda, Masahiro
Kamachi, Kenichi
Shinkai, Masaharu
author_sort Hirouchi, Takatomo
collection PubMed
description A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.
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spelling pubmed-75476112020-10-13 A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful Hirouchi, Takatomo Ota, Shinichiro Mashima, Dai Boku, Ryuichi Yoshida, Yuto Iwata, Koki Shinada, Kanako Matsumoto, Takashi Morikawa, Miwa Sato, Takashi Shinoda, Masahiro Kamachi, Kenichi Shinkai, Masaharu J Infect Chemother Case Report A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021-02 2020-10-10 /pmc/articles/PMC7547611/ /pubmed/33268271 http://dx.doi.org/10.1016/j.jiac.2020.10.011 Text en © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Hirouchi, Takatomo
Ota, Shinichiro
Mashima, Dai
Boku, Ryuichi
Yoshida, Yuto
Iwata, Koki
Shinada, Kanako
Matsumoto, Takashi
Morikawa, Miwa
Sato, Takashi
Shinoda, Masahiro
Kamachi, Kenichi
Shinkai, Masaharu
A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title_full A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title_fullStr A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title_full_unstemmed A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title_short A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
title_sort case of covid-19 pneumonia successfully treated with favipiravir (avigan) in which serum sars-cov-2 rna detected by lamp method was clinically useful
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547611/
https://www.ncbi.nlm.nih.gov/pubmed/33268271
http://dx.doi.org/10.1016/j.jiac.2020.10.011
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