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Large-scale dynamics of perceptual decision information across human cortex

Perceptual decisions entail the accumulation of sensory evidence for a particular choice towards an action plan. An influential framework holds that sensory cortical areas encode the instantaneous sensory evidence and downstream, action-related regions accumulate this evidence. The large-scale distr...

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Autores principales: Wilming, Niklas, Murphy, Peter R., Meyniel, Florent, Donner, Tobias H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547662/
https://www.ncbi.nlm.nih.gov/pubmed/33037209
http://dx.doi.org/10.1038/s41467-020-18826-6
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author Wilming, Niklas
Murphy, Peter R.
Meyniel, Florent
Donner, Tobias H.
author_facet Wilming, Niklas
Murphy, Peter R.
Meyniel, Florent
Donner, Tobias H.
author_sort Wilming, Niklas
collection PubMed
description Perceptual decisions entail the accumulation of sensory evidence for a particular choice towards an action plan. An influential framework holds that sensory cortical areas encode the instantaneous sensory evidence and downstream, action-related regions accumulate this evidence. The large-scale distribution of this computation across the cerebral cortex has remained largely elusive. Here, we develop a regionally-specific magnetoencephalography decoding approach to exhaustively map the dynamics of stimulus- and choice-specific signals across the human cortical surface during a visual decision. Comparison with the evidence accumulation dynamics inferred from behavior disentangles stimulus-dependent and endogenous components of choice-predictive activity across the visual cortical hierarchy. We find such an endogenous component in early visual cortex (including V1), which is expressed in a low (<20 Hz) frequency band and tracks, with delay, the build-up of choice-predictive activity in (pre-) motor regions. Our results are consistent with choice- and frequency-specific cortical feedback signaling during decision formation.
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spelling pubmed-75476622020-10-19 Large-scale dynamics of perceptual decision information across human cortex Wilming, Niklas Murphy, Peter R. Meyniel, Florent Donner, Tobias H. Nat Commun Article Perceptual decisions entail the accumulation of sensory evidence for a particular choice towards an action plan. An influential framework holds that sensory cortical areas encode the instantaneous sensory evidence and downstream, action-related regions accumulate this evidence. The large-scale distribution of this computation across the cerebral cortex has remained largely elusive. Here, we develop a regionally-specific magnetoencephalography decoding approach to exhaustively map the dynamics of stimulus- and choice-specific signals across the human cortical surface during a visual decision. Comparison with the evidence accumulation dynamics inferred from behavior disentangles stimulus-dependent and endogenous components of choice-predictive activity across the visual cortical hierarchy. We find such an endogenous component in early visual cortex (including V1), which is expressed in a low (<20 Hz) frequency band and tracks, with delay, the build-up of choice-predictive activity in (pre-) motor regions. Our results are consistent with choice- and frequency-specific cortical feedback signaling during decision formation. Nature Publishing Group UK 2020-10-09 /pmc/articles/PMC7547662/ /pubmed/33037209 http://dx.doi.org/10.1038/s41467-020-18826-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wilming, Niklas
Murphy, Peter R.
Meyniel, Florent
Donner, Tobias H.
Large-scale dynamics of perceptual decision information across human cortex
title Large-scale dynamics of perceptual decision information across human cortex
title_full Large-scale dynamics of perceptual decision information across human cortex
title_fullStr Large-scale dynamics of perceptual decision information across human cortex
title_full_unstemmed Large-scale dynamics of perceptual decision information across human cortex
title_short Large-scale dynamics of perceptual decision information across human cortex
title_sort large-scale dynamics of perceptual decision information across human cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547662/
https://www.ncbi.nlm.nih.gov/pubmed/33037209
http://dx.doi.org/10.1038/s41467-020-18826-6
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