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The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond
The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER pro...
Autores principales: | Wu, Zhiyi, Newstead, Simon, Biggin, Philip C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547670/ https://www.ncbi.nlm.nih.gov/pubmed/33037300 http://dx.doi.org/10.1038/s41598-020-73906-3 |
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