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The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond

The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER pro...

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Detalles Bibliográficos
Autores principales: Wu, Zhiyi, Newstead, Simon, Biggin, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547670/
https://www.ncbi.nlm.nih.gov/pubmed/33037300
http://dx.doi.org/10.1038/s41598-020-73906-3

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