Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

RB1 mutational inactivation is a cancer driver in various types of cancer including lung cancer, making it an important target for therapeutic exploitation. We performed chemical and genetic vulnerability screens in RB1-isogenic lung cancer pair and herein report that aurora kinase A (AURKA) inhibit...

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Detalles Bibliográficos
Autores principales: Lyu, Junfang, Yang, Eun Ju, Zhang, Baoyuan, Wu, Changjie, Pardeshi, Lakhansing, Shi, Changxiang, Mou, Pui Kei, Liu, Yifan, Tan, Kaeling, Shim, Joong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547687/
https://www.ncbi.nlm.nih.gov/pubmed/33037191
http://dx.doi.org/10.1038/s41467-020-18872-0

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