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Synthesis runs counter to directional folding of a nascent protein domain

Folding of individual domains in large proteins during translation helps to avoid otherwise prevalent inter-domain misfolding. How folding intermediates observed in vitro for the majority of proteins relate to co-translational folding remains unclear. Combining in vivo and single-molecule experiment...

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Detalles Bibliográficos
Autores principales:	Chen, Xiuqi, Rajasekaran, Nandakumar, Liu, Kaixian, Kaiser, Christian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547688/ https://www.ncbi.nlm.nih.gov/pubmed/33037221 http://dx.doi.org/10.1038/s41467-020-18921-8

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