Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4

The transcription factor TCF4 was confirmed in several large genome-wide association studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic mice moderately overexpressing Tcf4 in forebrain (Tcf4tg) display deficits in fear memory and sensorimotor gating. As second...

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Detalles Bibliográficos
Autores principales: Badowska, D. M., Brzózka, M. M., Kannaiyan, N., Thomas, C., Dibaj, P., Chowdhury, A., Steffens, H., Turck, C. W., Falkai, P., Schmitt, A., Papiol, S., Scheuss, V., Willig, K. I., Martins-de-Souza, D., Rhee, J. S., Malzahn, D., Rossner, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547694/
https://www.ncbi.nlm.nih.gov/pubmed/33037178
http://dx.doi.org/10.1038/s41398-020-01026-7

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