Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr(701) phosphorylation

ERBB2 is a ligand-less tyrosine kinase receptor expressed at very low levels in normal tissues; when overexpressed, it is involved in malignant transformation and tumorigenesis in several carcinomas. In cancer cells, ERBB2 represents the preferred partner of other members of the ERBB receptor family...

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Detalles Bibliográficos
Autores principales: Gaviraghi, Marco, Rabellino, Andrea, Andolfo, Annapaola, Brand, Matthias, Brombin, Chiara, Bagnato, Paola, De Feudis, Giuseppina, Raimondi, Andrea, Locatelli, Alberta, Tosoni, Daniela, Mazza, Davide, Gianni, Luca, Tonon, Giovanni, Yarden, Yosef, Tacchetti, Carlo, Daniele, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547737/
https://www.ncbi.nlm.nih.gov/pubmed/33037285
http://dx.doi.org/10.1038/s41598-020-73835-1

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