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Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study
OBJECTIVE: Due to the presence of pain during nasogastric tube (NGT) insertion and related complications and lack of positive clinical response of nasopharyngeal anesthesia with lidocaine and the related side effects and limitations in ketamine and intravenous midazolam, this study aims to determine...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547745/ https://www.ncbi.nlm.nih.gov/pubmed/33102386 http://dx.doi.org/10.4103/jrpp.JRPP_19_80 |
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author | Rouhi, Asghar Jafari Zeraatchi, Alireza Rahmani, Farzad Rouhi, Asghar Jafari Motamed, Nima Rastin, Ala Karami, Afsaneh Nejabatian, Arezoo |
author_facet | Rouhi, Asghar Jafari Zeraatchi, Alireza Rahmani, Farzad Rouhi, Asghar Jafari Motamed, Nima Rastin, Ala Karami, Afsaneh Nejabatian, Arezoo |
author_sort | Rouhi, Asghar Jafari |
collection | PubMed |
description | OBJECTIVE: Due to the presence of pain during nasogastric tube (NGT) insertion and related complications and lack of positive clinical response of nasopharyngeal anesthesia with lidocaine and the related side effects and limitations in ketamine and intravenous midazolam, this study aims to determine the efficacy of oral midazolam in relieving pain in the patients requiring NGT insertion. METHODS: A randomized, triple-blind clinical trial was performed on the patients in the Emergency Department of Zanjan Valiasr and Mousavi Hospitals in Iran, who were nominated for NGT. In each group, 100 patients were examined. Two milligram syrups of midazolam and placebo were administered 20 min before the procedure. In two groups, the pain based on the Visual Analog Scale and satisfaction rate of patients during the NGT insertion were compared. The data were analyzed through the SPSS software version 16.0. FINDINGS: There was no statistically significant difference in the demographic characteristics of two groups. Despite the effects of potential confounding variables, the cause of the referral and indication of NGT, as well as the use of midazolam syrup, had a significant relationship with the outcome, so that midazolam group experienced less pain. The mean and standard deviation of the examined outcomes (feeling of pain and satisfaction with NGT insertion) was statistically significantly different in the midazolam group as compared to the placebo group (P = 0.001). CONCLUSION: Midazolam was effective in decreasing pain and increasing the satisfaction of patients after NGT insertion. This manuscript is registered in Irct. com with code IRCT20110629006922N4. |
format | Online Article Text |
id | pubmed-7547745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-75477452020-10-22 Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study Rouhi, Asghar Jafari Zeraatchi, Alireza Rahmani, Farzad Rouhi, Asghar Jafari Motamed, Nima Rastin, Ala Karami, Afsaneh Nejabatian, Arezoo J Res Pharm Pract Original Article OBJECTIVE: Due to the presence of pain during nasogastric tube (NGT) insertion and related complications and lack of positive clinical response of nasopharyngeal anesthesia with lidocaine and the related side effects and limitations in ketamine and intravenous midazolam, this study aims to determine the efficacy of oral midazolam in relieving pain in the patients requiring NGT insertion. METHODS: A randomized, triple-blind clinical trial was performed on the patients in the Emergency Department of Zanjan Valiasr and Mousavi Hospitals in Iran, who were nominated for NGT. In each group, 100 patients were examined. Two milligram syrups of midazolam and placebo were administered 20 min before the procedure. In two groups, the pain based on the Visual Analog Scale and satisfaction rate of patients during the NGT insertion were compared. The data were analyzed through the SPSS software version 16.0. FINDINGS: There was no statistically significant difference in the demographic characteristics of two groups. Despite the effects of potential confounding variables, the cause of the referral and indication of NGT, as well as the use of midazolam syrup, had a significant relationship with the outcome, so that midazolam group experienced less pain. The mean and standard deviation of the examined outcomes (feeling of pain and satisfaction with NGT insertion) was statistically significantly different in the midazolam group as compared to the placebo group (P = 0.001). CONCLUSION: Midazolam was effective in decreasing pain and increasing the satisfaction of patients after NGT insertion. This manuscript is registered in Irct. com with code IRCT20110629006922N4. Wolters Kluwer - Medknow 2020-06-26 /pmc/articles/PMC7547745/ /pubmed/33102386 http://dx.doi.org/10.4103/jrpp.JRPP_19_80 Text en Copyright: © 2020 Journal of Research in Pharmacy Practice http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Rouhi, Asghar Jafari Zeraatchi, Alireza Rahmani, Farzad Rouhi, Asghar Jafari Motamed, Nima Rastin, Ala Karami, Afsaneh Nejabatian, Arezoo Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title | Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title_full | Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title_fullStr | Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title_full_unstemmed | Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title_short | Effect of Oral Midazolam in Pain Relief of Patients Need Nasogastric Tube Insertion: A Clinical Trial Study |
title_sort | effect of oral midazolam in pain relief of patients need nasogastric tube insertion: a clinical trial study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547745/ https://www.ncbi.nlm.nih.gov/pubmed/33102386 http://dx.doi.org/10.4103/jrpp.JRPP_19_80 |
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