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Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents
PURPOSE: Salicyl (Sal) – among other oxygen functionalities – multi-walled carbon nanotubes (MWCNTs) and their nanohybrids are investigated as promising contrast agents (CA) in magnetic resonance imaging (MRI) or drug delivery platforms, due to their unique properties. The preliminary results and th...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547780/ https://www.ncbi.nlm.nih.gov/pubmed/33116480 http://dx.doi.org/10.2147/IJN.S257230 |
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author | Tomczyk, Mateusz Michał Boncel, Sławomir Herman, Artur Krawczyk, Tomasz Jakóbik-Kolon, Agata Pawlyta, Mirosława Krzywiecki, Maciej Chrobak, Artur Minoshima, Masafumi Sugihara, Fuminori Kikuchi, Kazuya Kuźnik, Nikodem |
author_facet | Tomczyk, Mateusz Michał Boncel, Sławomir Herman, Artur Krawczyk, Tomasz Jakóbik-Kolon, Agata Pawlyta, Mirosława Krzywiecki, Maciej Chrobak, Artur Minoshima, Masafumi Sugihara, Fuminori Kikuchi, Kazuya Kuźnik, Nikodem |
author_sort | Tomczyk, Mateusz Michał |
collection | PubMed |
description | PURPOSE: Salicyl (Sal) – among other oxygen functionalities – multi-walled carbon nanotubes (MWCNTs) and their nanohybrids are investigated as promising contrast agents (CA) in magnetic resonance imaging (MRI) or drug delivery platforms, due to their unique properties. The preliminary results and the literature reports were the motivation to endow high r(2) relaxivities, excellent dispersibility in water, and biocompatibility to superparamagnetic MWCNTs nanohybrids. It was hypothesized that these goals could be achieved by, not described in the literature yet, two-stage oxygen functionalization of MWCNTs. RESULTS: Two structurally different MWCNT materials differing in diameters (44 and 12 nm) and the iron content (4.7% and 0.5%) are studied toward the functionalization effect on the T(2) relaxometric properties. MWCNT oxidation is typically the first step of functionalization resulting in “first generation” oxygen functional groups (OFGs) on the surface. Until now, the impact of OFGs on the relaxivity of MWCNT was not truly recognized, but this study sheds light on this issue. By follow-up functionalization of oxidized MWCNT with 4-azidosalicylic acid through [2+1] cycloaddition of the corresponding nitrene, “second generation” of oxygen functional groups is grafted onto the nanohybrid, ie, Sal functionality. CONCLUSION: The introduced OFGs are responsible for an almost 30% increase in the relaxivity, which leads to remarkable r(2) relaxivity of 951 mM(−1)s(−1) (419 (mg/mL)(−1)s(−1)), the unprecedented value reported to date for this class of CAs. Also, the resulting nanohybrids express low cytotoxicity and superb diffusion after subcutaneous injection to a mouse. |
format | Online Article Text |
id | pubmed-7547780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75477802020-10-27 Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents Tomczyk, Mateusz Michał Boncel, Sławomir Herman, Artur Krawczyk, Tomasz Jakóbik-Kolon, Agata Pawlyta, Mirosława Krzywiecki, Maciej Chrobak, Artur Minoshima, Masafumi Sugihara, Fuminori Kikuchi, Kazuya Kuźnik, Nikodem Int J Nanomedicine Original Research PURPOSE: Salicyl (Sal) – among other oxygen functionalities – multi-walled carbon nanotubes (MWCNTs) and their nanohybrids are investigated as promising contrast agents (CA) in magnetic resonance imaging (MRI) or drug delivery platforms, due to their unique properties. The preliminary results and the literature reports were the motivation to endow high r(2) relaxivities, excellent dispersibility in water, and biocompatibility to superparamagnetic MWCNTs nanohybrids. It was hypothesized that these goals could be achieved by, not described in the literature yet, two-stage oxygen functionalization of MWCNTs. RESULTS: Two structurally different MWCNT materials differing in diameters (44 and 12 nm) and the iron content (4.7% and 0.5%) are studied toward the functionalization effect on the T(2) relaxometric properties. MWCNT oxidation is typically the first step of functionalization resulting in “first generation” oxygen functional groups (OFGs) on the surface. Until now, the impact of OFGs on the relaxivity of MWCNT was not truly recognized, but this study sheds light on this issue. By follow-up functionalization of oxidized MWCNT with 4-azidosalicylic acid through [2+1] cycloaddition of the corresponding nitrene, “second generation” of oxygen functional groups is grafted onto the nanohybrid, ie, Sal functionality. CONCLUSION: The introduced OFGs are responsible for an almost 30% increase in the relaxivity, which leads to remarkable r(2) relaxivity of 951 mM(−1)s(−1) (419 (mg/mL)(−1)s(−1)), the unprecedented value reported to date for this class of CAs. Also, the resulting nanohybrids express low cytotoxicity and superb diffusion after subcutaneous injection to a mouse. Dove 2020-10-06 /pmc/articles/PMC7547780/ /pubmed/33116480 http://dx.doi.org/10.2147/IJN.S257230 Text en © 2020 Tomczyk et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Tomczyk, Mateusz Michał Boncel, Sławomir Herman, Artur Krawczyk, Tomasz Jakóbik-Kolon, Agata Pawlyta, Mirosława Krzywiecki, Maciej Chrobak, Artur Minoshima, Masafumi Sugihara, Fuminori Kikuchi, Kazuya Kuźnik, Nikodem Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title | Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title_full | Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title_fullStr | Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title_full_unstemmed | Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title_short | Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T(2) Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents |
title_sort | oxygen functional groups on mwcnt surface as critical factor boosting t(2) relaxation rate of water protons: towards improved cnt-based contrast agents |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547780/ https://www.ncbi.nlm.nih.gov/pubmed/33116480 http://dx.doi.org/10.2147/IJN.S257230 |
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