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Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes
[Image: see text] Origins of life hypotheses often invoke a transitional phase of nonenzymatic template-directed RNA replication prior to the emergence of ribozyme-catalyzed copying of genetic information. Here, using NMR and ITC, we interrogate the binding affinity of guanosine 5′-monophosphate (GM...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547879/ https://www.ncbi.nlm.nih.gov/pubmed/28055190 http://dx.doi.org/10.1021/jacs.6b09760 |