Transfer of Sequence Information and Replication of Diimine Duplexes

[Image: see text] The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was e...

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Autores principales: Strom, Kyle R., Szostak, Jack W., Prywes, Noam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547894/
https://www.ncbi.nlm.nih.gov/pubmed/30855962
http://dx.doi.org/10.1021/acs.joc.9b00095
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author Strom, Kyle R.
Szostak, Jack W.
Prywes, Noam
author_facet Strom, Kyle R.
Szostak, Jack W.
Prywes, Noam
author_sort Strom, Kyle R.
collection PubMed
description [Image: see text] The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was encoded as a sequence of aniline and benzaldehyde subunits linked together by a diethynyl benzene backbone. These dimers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates for the synthesis of daughter duplexes with identical sequences.
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spelling pubmed-75478942020-10-13 Transfer of Sequence Information and Replication of Diimine Duplexes Strom, Kyle R. Szostak, Jack W. Prywes, Noam J Org Chem [Image: see text] The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was encoded as a sequence of aniline and benzaldehyde subunits linked together by a diethynyl benzene backbone. These dimers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates for the synthesis of daughter duplexes with identical sequences. American Chemical Society 2019-03-11 2019-04-05 /pmc/articles/PMC7547894/ /pubmed/30855962 http://dx.doi.org/10.1021/acs.joc.9b00095 Text en This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Strom, Kyle R.
Szostak, Jack W.
Prywes, Noam
Transfer of Sequence Information and Replication of Diimine Duplexes
title Transfer of Sequence Information and Replication of Diimine Duplexes
title_full Transfer of Sequence Information and Replication of Diimine Duplexes
title_fullStr Transfer of Sequence Information and Replication of Diimine Duplexes
title_full_unstemmed Transfer of Sequence Information and Replication of Diimine Duplexes
title_short Transfer of Sequence Information and Replication of Diimine Duplexes
title_sort transfer of sequence information and replication of diimine duplexes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547894/
https://www.ncbi.nlm.nih.gov/pubmed/30855962
http://dx.doi.org/10.1021/acs.joc.9b00095
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