Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution

SIGNIFICANCE: Midday fogging of scleral contact lenses requires frequent lens removal and reapplication for a large portion of lens wearers. Using a lens filling solution that mimics the composition of tears is hypothesized to have an impact on the production of material trapped under a scleral lens...

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Autores principales: Fogt, Jennifer Swingle, Karres, Matthew, Barr, Joseph T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547899/
https://www.ncbi.nlm.nih.gov/pubmed/32941340
http://dx.doi.org/10.1097/OPX.0000000000001559
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author Fogt, Jennifer Swingle
Karres, Matthew
Barr, Joseph T.
author_facet Fogt, Jennifer Swingle
Karres, Matthew
Barr, Joseph T.
author_sort Fogt, Jennifer Swingle
collection PubMed
description SIGNIFICANCE: Midday fogging of scleral contact lenses requires frequent lens removal and reapplication for a large portion of lens wearers. Using a lens filling solution that mimics the composition of tears is hypothesized to have an impact on the production of material trapped under a scleral lens. PURPOSE: The purposes of this open-label study were to assess the safety of a scleral lens filling solution, which closely approximates the ionic concentration and pH of human tears, and to assess signs and symptoms of midday fogging with this formulation and with subjects' habitual sodium chloride solutions. METHODS: Existing scleral lens wearers with midday fogging (N = 22) were examined and completed surveys of symptoms. Subjects filled the concavity of their current lenses with test solution and were assessed immediately and approximately 4 hours later for safety monitoring. Test solution was dispensed and used for 5 to 9 days when subjects were reexamined and repeated the surveys. Biomicroscopy and anterior optical coherence tomography images were used to assess midday fogging objectively. RESULTS: The median (interquartile range) Ocular Surface Disease Index score decreased from 27.1 (21.7) U when using habitual filling solution to 9.1 (20.1) U when using the test solution (P = .006). Current Symptoms Survey findings with the test solution compared with habitual solution resulted in statistically significant decreases in burning/stinging (P = .04), grittiness/foreign body sensation (P = .01), dryness (P = .002), blurry/fluctuating vision (P = .002), and overall pain/discomfort (P = .006). Objective assessment of corneal staining and fogging revealed decreases that were not statistically significant in this small sample size. CONCLUSIONS: This study establishes the safety and subject tolerance of a scleral lens filling solution that mimics the ionic composition of human tears. Significant improvements in subjective ratings, although likely biased in this unmasked trial, suggest that further studies of the effectiveness of this solution in reducing midday fogging are warranted.
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spelling pubmed-75478992020-10-29 Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution Fogt, Jennifer Swingle Karres, Matthew Barr, Joseph T. Optom Vis Sci Original Investigations SIGNIFICANCE: Midday fogging of scleral contact lenses requires frequent lens removal and reapplication for a large portion of lens wearers. Using a lens filling solution that mimics the composition of tears is hypothesized to have an impact on the production of material trapped under a scleral lens. PURPOSE: The purposes of this open-label study were to assess the safety of a scleral lens filling solution, which closely approximates the ionic concentration and pH of human tears, and to assess signs and symptoms of midday fogging with this formulation and with subjects' habitual sodium chloride solutions. METHODS: Existing scleral lens wearers with midday fogging (N = 22) were examined and completed surveys of symptoms. Subjects filled the concavity of their current lenses with test solution and were assessed immediately and approximately 4 hours later for safety monitoring. Test solution was dispensed and used for 5 to 9 days when subjects were reexamined and repeated the surveys. Biomicroscopy and anterior optical coherence tomography images were used to assess midday fogging objectively. RESULTS: The median (interquartile range) Ocular Surface Disease Index score decreased from 27.1 (21.7) U when using habitual filling solution to 9.1 (20.1) U when using the test solution (P = .006). Current Symptoms Survey findings with the test solution compared with habitual solution resulted in statistically significant decreases in burning/stinging (P = .04), grittiness/foreign body sensation (P = .01), dryness (P = .002), blurry/fluctuating vision (P = .002), and overall pain/discomfort (P = .006). Objective assessment of corneal staining and fogging revealed decreases that were not statistically significant in this small sample size. CONCLUSIONS: This study establishes the safety and subject tolerance of a scleral lens filling solution that mimics the ionic composition of human tears. Significant improvements in subjective ratings, although likely biased in this unmasked trial, suggest that further studies of the effectiveness of this solution in reducing midday fogging are warranted. Lippincott Williams & Wilkins 2020-09 2020-09-16 /pmc/articles/PMC7547899/ /pubmed/32941340 http://dx.doi.org/10.1097/OPX.0000000000001559 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Optometry. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Investigations
Fogt, Jennifer Swingle
Karres, Matthew
Barr, Joseph T.
Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title_full Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title_fullStr Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title_full_unstemmed Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title_short Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution
title_sort changes in symptoms of midday fogging with a novel scleral contact lens filling solution
topic Original Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547899/
https://www.ncbi.nlm.nih.gov/pubmed/32941340
http://dx.doi.org/10.1097/OPX.0000000000001559
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