Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma

BACKGROUND: p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous cell carcinoma (HNSCC) cell death. METHODS: CAL-27 and SCC-25 cells we...

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Detalles Bibliográficos
Autores principales: Liu, Zhe, Hurst, Douglas R., Qu, Xing, Lu, Li-Guang, Wu, Chen-Zhou, Li, Yu-Yu, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548045/
https://www.ncbi.nlm.nih.gov/pubmed/33038921
http://dx.doi.org/10.1186/s40779-020-00275-3

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