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Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study
BACKGROUND: Omitting axillary lymph node dissection (ALND) is recommended for early-stage breast cancer patients with 1–2 sentinel lymph nodes (SLNs) macro-metastases and breast-conserving therapy. However, it is not safe for part of patients, so it is significant to find risk factors and develop a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548499/ https://www.ncbi.nlm.nih.gov/pubmed/33083292 http://dx.doi.org/10.18502/ijph.v49i7.3579 |
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author | WANG, Xiangyu GAO, Yinqi YANG, Xue KONG, Xiangyi WANG, Zixing FANG, Yi WANG, Jing |
author_facet | WANG, Xiangyu GAO, Yinqi YANG, Xue KONG, Xiangyi WANG, Zixing FANG, Yi WANG, Jing |
author_sort | WANG, Xiangyu |
collection | PubMed |
description | BACKGROUND: Omitting axillary lymph node dissection (ALND) is recommended for early-stage breast cancer patients with 1–2 sentinel lymph nodes (SLNs) macro-metastases and breast-conserving therapy. However, it is not safe for part of patients, so it is significant to find risk factors and develop a predictive model of non-SLNs metastases in breast cancer patients with 1–2 SLNs macro-metastases and breast-conserving therapy. METHODS: This retrospective study enrolled 228 breast cancer patients with 1–2 SLNs macro-metastases who underwent ALND and breast-conserving surgery between Jan 2012 and Dec 2017 at Cancer Hospital Chinese Academy of Medical Sciences. Chi-square test and backward stepwise binary logistic regression were used to find factors that influenced non-SLN metastases, then a predictive model was formulated and obtained its area under the curve. RESULTS: Tumor pathologic invasion size, number of positive SLNs and ALN status on imaging was associated with non-SLNs metastases. The predictive model was also formulated based on these three factors to assess and the area under the curve of model was 0.708. CONCLUSION: We developed a predictive model to assess the high-risk cohort of patients of non-SLNs metastases which can be an auxiliary tool for doctors. |
format | Online Article Text |
id | pubmed-7548499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-75484992020-10-19 Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study WANG, Xiangyu GAO, Yinqi YANG, Xue KONG, Xiangyi WANG, Zixing FANG, Yi WANG, Jing Iran J Public Health Original Article BACKGROUND: Omitting axillary lymph node dissection (ALND) is recommended for early-stage breast cancer patients with 1–2 sentinel lymph nodes (SLNs) macro-metastases and breast-conserving therapy. However, it is not safe for part of patients, so it is significant to find risk factors and develop a predictive model of non-SLNs metastases in breast cancer patients with 1–2 SLNs macro-metastases and breast-conserving therapy. METHODS: This retrospective study enrolled 228 breast cancer patients with 1–2 SLNs macro-metastases who underwent ALND and breast-conserving surgery between Jan 2012 and Dec 2017 at Cancer Hospital Chinese Academy of Medical Sciences. Chi-square test and backward stepwise binary logistic regression were used to find factors that influenced non-SLN metastases, then a predictive model was formulated and obtained its area under the curve. RESULTS: Tumor pathologic invasion size, number of positive SLNs and ALN status on imaging was associated with non-SLNs metastases. The predictive model was also formulated based on these three factors to assess and the area under the curve of model was 0.708. CONCLUSION: We developed a predictive model to assess the high-risk cohort of patients of non-SLNs metastases which can be an auxiliary tool for doctors. Tehran University of Medical Sciences 2020-07 /pmc/articles/PMC7548499/ /pubmed/33083292 http://dx.doi.org/10.18502/ijph.v49i7.3579 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article WANG, Xiangyu GAO, Yinqi YANG, Xue KONG, Xiangyi WANG, Zixing FANG, Yi WANG, Jing Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title | Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title_full | Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title_fullStr | Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title_full_unstemmed | Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title_short | Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1–2 SLNs Macro-Metastases and Breast-Conserving Therapy: A Single-Center Retrospective Study |
title_sort | omitting alnd is not safe for a cohort of early-stage breast cancer patients with 1–2 slns macro-metastases and breast-conserving therapy: a single-center retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548499/ https://www.ncbi.nlm.nih.gov/pubmed/33083292 http://dx.doi.org/10.18502/ijph.v49i7.3579 |
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