Cargando…

Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report

A 52-year-old African-American woman with a prior history of monoclonal gammopathy of undetermined significance (MGUS) developed infiltrating ductal carcinoma of the left breast. Following a mastectomy, she underwent reconstruction with a silicone gel breast implant. Three years later, her MGUS had...

Descripción completa

Detalles Bibliográficos
Autores principales: Henning, Chace, Wang, James, Swift, Regina, Eades, Benjamin, Spektor, Tanya M., Berenson, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548844/
https://www.ncbi.nlm.nih.gov/pubmed/33082755
http://dx.doi.org/10.1159/000508494
_version_ 1783592699026210816
author Henning, Chace
Wang, James
Swift, Regina
Eades, Benjamin
Spektor, Tanya M.
Berenson, James R.
author_facet Henning, Chace
Wang, James
Swift, Regina
Eades, Benjamin
Spektor, Tanya M.
Berenson, James R.
author_sort Henning, Chace
collection PubMed
description A 52-year-old African-American woman with a prior history of monoclonal gammopathy of undetermined significance (MGUS) developed infiltrating ductal carcinoma of the left breast. Following a mastectomy, she underwent reconstruction with a silicone gel breast implant. Three years later, her MGUS had progressed to active multiple myeloma (MM). She had a minimal response after two different regimens of bortezomib-based treatments and monthly zoledronic acid, and was placed on maintenance therapy with bortezomib, intravenous dexamethasone, and oral methylprednisolone, as well as ongoing monthly zoledronic acid. After 1 year of this maintenance therapy, during which her myeloma markers remained unchanged, she had her silicone implant replaced with saline. Despite no change in her myeloma treatment, her laboratory values began to steadily improve following removal of the silicone implant. Her M-protein decreased from 2.14 to 0.83 g/dL and her IgG levels from 3,330 to 1,210 mg/dL following replacement of her silicone implant with saline. To our knowledge, this is the first report in which removal of silicone implants improved the clinical status of a patient with MM following a year of maintenance therapy during which the patient's myeloma laboratory values remained unchanged. Further studies are warranted to determine if silicone breast implant removal can, in fact, improve MM patients' disease status.
format Online
Article
Text
id pubmed-7548844
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-75488442020-10-19 Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report Henning, Chace Wang, James Swift, Regina Eades, Benjamin Spektor, Tanya M. Berenson, James R. Case Rep Oncol Case Report A 52-year-old African-American woman with a prior history of monoclonal gammopathy of undetermined significance (MGUS) developed infiltrating ductal carcinoma of the left breast. Following a mastectomy, she underwent reconstruction with a silicone gel breast implant. Three years later, her MGUS had progressed to active multiple myeloma (MM). She had a minimal response after two different regimens of bortezomib-based treatments and monthly zoledronic acid, and was placed on maintenance therapy with bortezomib, intravenous dexamethasone, and oral methylprednisolone, as well as ongoing monthly zoledronic acid. After 1 year of this maintenance therapy, during which her myeloma markers remained unchanged, she had her silicone implant replaced with saline. Despite no change in her myeloma treatment, her laboratory values began to steadily improve following removal of the silicone implant. Her M-protein decreased from 2.14 to 0.83 g/dL and her IgG levels from 3,330 to 1,210 mg/dL following replacement of her silicone implant with saline. To our knowledge, this is the first report in which removal of silicone implants improved the clinical status of a patient with MM following a year of maintenance therapy during which the patient's myeloma laboratory values remained unchanged. Further studies are warranted to determine if silicone breast implant removal can, in fact, improve MM patients' disease status. S. Karger AG 2020-09-18 /pmc/articles/PMC7548844/ /pubmed/33082755 http://dx.doi.org/10.1159/000508494 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Henning, Chace
Wang, James
Swift, Regina
Eades, Benjamin
Spektor, Tanya M.
Berenson, James R.
Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title_full Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title_fullStr Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title_full_unstemmed Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title_short Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report
title_sort removal of a silicone gel breast implant in a multiple myeloma patient improved disease status: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548844/
https://www.ncbi.nlm.nih.gov/pubmed/33082755
http://dx.doi.org/10.1159/000508494
work_keys_str_mv AT henningchace removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport
AT wangjames removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport
AT swiftregina removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport
AT eadesbenjamin removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport
AT spektortanyam removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport
AT berensonjamesr removalofasiliconegelbreastimplantinamultiplemyelomapatientimproveddiseasestatusacasereport