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Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study

BACKGROUND: Vitamin D plays a significant role in the function of the immune system and it influences many dermatological diseases such as psoriasis and atopic dermatitis. The prevalence of vitamin D deficiency is growing globally, with around 30–50% of people are known to have low levels of vitamin...

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Autores principales: Alhetheli, Ghadah, Elneam, Ahmed Ibrahim Abd, Alsenaid, Adel, Al-Dhubaibi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549021/
https://www.ncbi.nlm.nih.gov/pubmed/33116739
http://dx.doi.org/10.2147/CCID.S271500
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author Alhetheli, Ghadah
Elneam, Ahmed Ibrahim Abd
Alsenaid, Adel
Al-Dhubaibi, Mohammed
author_facet Alhetheli, Ghadah
Elneam, Ahmed Ibrahim Abd
Alsenaid, Adel
Al-Dhubaibi, Mohammed
author_sort Alhetheli, Ghadah
collection PubMed
description BACKGROUND: Vitamin D plays a significant role in the function of the immune system and it influences many dermatological diseases such as psoriasis and atopic dermatitis. The prevalence of vitamin D deficiency is growing globally, with around 30–50% of people are known to have low levels of vitamin D. Acne vulgaris is a common inflammatory disorder of the pilosebaceous unit. Studies about the role of vitamin D in the pathogenesis of acne vulgaris have shown conflicting and nonconclusive results. Thus, the precise purpose of vitamin D has not yet been established. OBJECTIVE: First, to evaluate serum levels of vitamin D through a representative sample of patients with acne vulgaris and compare it with matched healthy controls. Second, to investigate if there is a relation between serum vitamin D level and the severity of acne vulgaris. MATERIALS AND METHODS: This cross-sectional study included 68 patients with acne vulgaris and 50 matched healthy controls. Serum 25-hydroxyvitamin D [25 (OH) D] levels were measured for both patients and healthy controls. RESULTS: The study yielded lower levels of serum 25-hydroxyvitamin D in patients with acne vulgaris than its level in healthy controls. This is statistically significant with P-value = 0.003. Regarding age, gender, and sun exposure, there is no significant variation in serum 25-hydroxyvitamin D level. Also, no significant difference between the severity of acne and serum 25-hydroxyvitamin D levels. CONCLUSION: This study has shown clearly that vitamin D deficiency is more frequent in patients with acne with P-value = 0.003. However, no significant association between the serum level of 25-hydroxyvitamin D [25 (OH) D] and the severity of acne vulgaris. Further clinical trials on a larger scale are needed to address the importance of vitamin D in acne vulgaris. Specifically, determining whether treatment of acne with both topical vitamin D analogs and vitamin D supplementation is of significant effect.
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spelling pubmed-75490212020-10-27 Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study Alhetheli, Ghadah Elneam, Ahmed Ibrahim Abd Alsenaid, Adel Al-Dhubaibi, Mohammed Clin Cosmet Investig Dermatol Original Research BACKGROUND: Vitamin D plays a significant role in the function of the immune system and it influences many dermatological diseases such as psoriasis and atopic dermatitis. The prevalence of vitamin D deficiency is growing globally, with around 30–50% of people are known to have low levels of vitamin D. Acne vulgaris is a common inflammatory disorder of the pilosebaceous unit. Studies about the role of vitamin D in the pathogenesis of acne vulgaris have shown conflicting and nonconclusive results. Thus, the precise purpose of vitamin D has not yet been established. OBJECTIVE: First, to evaluate serum levels of vitamin D through a representative sample of patients with acne vulgaris and compare it with matched healthy controls. Second, to investigate if there is a relation between serum vitamin D level and the severity of acne vulgaris. MATERIALS AND METHODS: This cross-sectional study included 68 patients with acne vulgaris and 50 matched healthy controls. Serum 25-hydroxyvitamin D [25 (OH) D] levels were measured for both patients and healthy controls. RESULTS: The study yielded lower levels of serum 25-hydroxyvitamin D in patients with acne vulgaris than its level in healthy controls. This is statistically significant with P-value = 0.003. Regarding age, gender, and sun exposure, there is no significant variation in serum 25-hydroxyvitamin D level. Also, no significant difference between the severity of acne and serum 25-hydroxyvitamin D levels. CONCLUSION: This study has shown clearly that vitamin D deficiency is more frequent in patients with acne with P-value = 0.003. However, no significant association between the serum level of 25-hydroxyvitamin D [25 (OH) D] and the severity of acne vulgaris. Further clinical trials on a larger scale are needed to address the importance of vitamin D in acne vulgaris. Specifically, determining whether treatment of acne with both topical vitamin D analogs and vitamin D supplementation is of significant effect. Dove 2020-10-07 /pmc/articles/PMC7549021/ /pubmed/33116739 http://dx.doi.org/10.2147/CCID.S271500 Text en © 2020 Alhetheli et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Alhetheli, Ghadah
Elneam, Ahmed Ibrahim Abd
Alsenaid, Adel
Al-Dhubaibi, Mohammed
Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title_full Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title_fullStr Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title_full_unstemmed Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title_short Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study
title_sort vitamin d levels in patients with and without acne and its relation to acne severity: a case-control study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549021/
https://www.ncbi.nlm.nih.gov/pubmed/33116739
http://dx.doi.org/10.2147/CCID.S271500
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