CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting specificity, addressing histocompatibility leukoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Preece, Roland, Pavesi, Andrea, Gkazi, Soragia Athina, Stegmann, Kerstin A., Georgiadis, Christos, Tan, Zhi Ming, Aw, Jia Ying Joey, Maini, Mala K., Bertoletti, Antonio, Qasim, Waseem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549055/
https://www.ncbi.nlm.nih.gov/pubmed/33102612
http://dx.doi.org/10.1016/j.omtm.2020.09.002

Ejemplares similares

Ejemplares similares