A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation

We presented a patient with CML who progressed to unclassical blast phase after Tyrosine Kinase Inhibitors (TKIs) therapy. The patient presented with 2 populations of blasts: one with no cytoplasmic granules and was CD117 weak+/tryptase-/CD34- (typical myeloblasts), and another with metochromatic gr...

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Detalles Bibliográficos
Autores principales: Song, Jinming, Liu, Kenian, Pinilla-Ibarz, Javier, Zhang, Hailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549112/
https://www.ncbi.nlm.nih.gov/pubmed/33072512
http://dx.doi.org/10.1016/j.lrr.2020.100222
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author Song, Jinming
Liu, Kenian
Pinilla-Ibarz, Javier
Zhang, Hailing
author_facet Song, Jinming
Liu, Kenian
Pinilla-Ibarz, Javier
Zhang, Hailing
author_sort Song, Jinming
collection PubMed
description We presented a patient with CML who progressed to unclassical blast phase after Tyrosine Kinase Inhibitors (TKIs) therapy. The patient presented with 2 populations of blasts: one with no cytoplasmic granules and was CD117 weak+/tryptase-/CD34- (typical myeloblasts), and another with metochromatic granules in the cytoplasm and was CD117 strong+/tryptase+/CD25+/CD34 subset+ (myelomastocytic blasts). Almost all the cells were positive for BCR/ABL1 fusion and no KT V816F mutation was detected. The patient was misdiagnosed as having blast phase CML with coexisting mast cell leukemia at an outside institute. Three similar cases and previously described myelomastocytic leukemia are reviewed and discussed.
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spelling pubmed-75491122020-10-16 A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation Song, Jinming Liu, Kenian Pinilla-Ibarz, Javier Zhang, Hailing Leuk Res Rep Article We presented a patient with CML who progressed to unclassical blast phase after Tyrosine Kinase Inhibitors (TKIs) therapy. The patient presented with 2 populations of blasts: one with no cytoplasmic granules and was CD117 weak+/tryptase-/CD34- (typical myeloblasts), and another with metochromatic granules in the cytoplasm and was CD117 strong+/tryptase+/CD25+/CD34 subset+ (myelomastocytic blasts). Almost all the cells were positive for BCR/ABL1 fusion and no KT V816F mutation was detected. The patient was misdiagnosed as having blast phase CML with coexisting mast cell leukemia at an outside institute. Three similar cases and previously described myelomastocytic leukemia are reviewed and discussed. Elsevier 2020-09-28 /pmc/articles/PMC7549112/ /pubmed/33072512 http://dx.doi.org/10.1016/j.lrr.2020.100222 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Song, Jinming
Liu, Kenian
Pinilla-Ibarz, Javier
Zhang, Hailing
A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title_full A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title_fullStr A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title_full_unstemmed A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title_short A case report and case review: Chronic myeloid leukemia (CML) blast phase with myelomastocytic differentiation
title_sort case report and case review: chronic myeloid leukemia (cml) blast phase with myelomastocytic differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549112/
https://www.ncbi.nlm.nih.gov/pubmed/33072512
http://dx.doi.org/10.1016/j.lrr.2020.100222
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