LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodi...

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Autores principales: Taiana, Elisa, Ronchetti, Domenica, Todoerti, Katia, Nobili, Lucia, Tassone, Pierfrancesco, Amodio, Nicola, Neri, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549348/
https://www.ncbi.nlm.nih.gov/pubmed/32630183
http://dx.doi.org/10.3390/ncrna6030026
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author Taiana, Elisa
Ronchetti, Domenica
Todoerti, Katia
Nobili, Lucia
Tassone, Pierfrancesco
Amodio, Nicola
Neri, Antonino
author_facet Taiana, Elisa
Ronchetti, Domenica
Todoerti, Katia
Nobili, Lucia
Tassone, Pierfrancesco
Amodio, Nicola
Neri, Antonino
author_sort Taiana, Elisa
collection PubMed
description Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
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spelling pubmed-75493482020-10-15 LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? Taiana, Elisa Ronchetti, Domenica Todoerti, Katia Nobili, Lucia Tassone, Pierfrancesco Amodio, Nicola Neri, Antonino Noncoding RNA Review Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases. MDPI 2020-07-01 /pmc/articles/PMC7549348/ /pubmed/32630183 http://dx.doi.org/10.3390/ncrna6030026 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Taiana, Elisa
Ronchetti, Domenica
Todoerti, Katia
Nobili, Lucia
Tassone, Pierfrancesco
Amodio, Nicola
Neri, Antonino
LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title_full LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title_fullStr LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title_full_unstemmed LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title_short LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
title_sort lncrna neat1 in paraspeckles: a structural scaffold for cellular dna damage response systems?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549348/
https://www.ncbi.nlm.nih.gov/pubmed/32630183
http://dx.doi.org/10.3390/ncrna6030026
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