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LncRNAs in Non-Small-Cell Lung Cancer

Lung cancer is associated with a high mortality, with around 1.8 million deaths worldwide in 2018. Non-small-cell lung cancer (NSCLC) accounts for around 85% of cases and, despite improvement in the management of NSCLC, most patients are diagnosed at advanced stage and the five-year survival remains...

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Autores principales: Ginn, Lucy, Shi, Lei, La Montagna, Manuela, Garofalo, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549371/
https://www.ncbi.nlm.nih.gov/pubmed/32629922
http://dx.doi.org/10.3390/ncrna6030025
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author Ginn, Lucy
Shi, Lei
La Montagna, Manuela
Garofalo, Michela
author_facet Ginn, Lucy
Shi, Lei
La Montagna, Manuela
Garofalo, Michela
author_sort Ginn, Lucy
collection PubMed
description Lung cancer is associated with a high mortality, with around 1.8 million deaths worldwide in 2018. Non-small-cell lung cancer (NSCLC) accounts for around 85% of cases and, despite improvement in the management of NSCLC, most patients are diagnosed at advanced stage and the five-year survival remains around 15%. This highlights a need to identify novel ways to treat the disease to reduce the burden of NSCLC. Long non-coding RNAs (lncRNAs) are non-coding RNA molecules longer than 200 nucleotides in length which play important roles in gene expression and signaling pathways. Recently, lncRNAs were implicated in cancer, where their expression is dysregulated resulting in aberrant functions. LncRNAs were shown to function as both tumor suppressors and oncogenes in a variety of cancer types. Although there are a few well characterized lncRNAs in NSCLC, many lncRNAs remain un-characterized and their mechanisms of action largely unknown. LncRNAs have success as therapies in neurodegenerative diseases, and having a detailed understanding of their function in NSCLC may guide novel therapeutic approaches and strategies. This review discusses the role of lncRNAs in NSCLC tumorigenesis, highlighting their mechanisms of action and their clinical potential.
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spelling pubmed-75493712020-10-15 LncRNAs in Non-Small-Cell Lung Cancer Ginn, Lucy Shi, Lei La Montagna, Manuela Garofalo, Michela Noncoding RNA Review Lung cancer is associated with a high mortality, with around 1.8 million deaths worldwide in 2018. Non-small-cell lung cancer (NSCLC) accounts for around 85% of cases and, despite improvement in the management of NSCLC, most patients are diagnosed at advanced stage and the five-year survival remains around 15%. This highlights a need to identify novel ways to treat the disease to reduce the burden of NSCLC. Long non-coding RNAs (lncRNAs) are non-coding RNA molecules longer than 200 nucleotides in length which play important roles in gene expression and signaling pathways. Recently, lncRNAs were implicated in cancer, where their expression is dysregulated resulting in aberrant functions. LncRNAs were shown to function as both tumor suppressors and oncogenes in a variety of cancer types. Although there are a few well characterized lncRNAs in NSCLC, many lncRNAs remain un-characterized and their mechanisms of action largely unknown. LncRNAs have success as therapies in neurodegenerative diseases, and having a detailed understanding of their function in NSCLC may guide novel therapeutic approaches and strategies. This review discusses the role of lncRNAs in NSCLC tumorigenesis, highlighting their mechanisms of action and their clinical potential. MDPI 2020-06-30 /pmc/articles/PMC7549371/ /pubmed/32629922 http://dx.doi.org/10.3390/ncrna6030025 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ginn, Lucy
Shi, Lei
La Montagna, Manuela
Garofalo, Michela
LncRNAs in Non-Small-Cell Lung Cancer
title LncRNAs in Non-Small-Cell Lung Cancer
title_full LncRNAs in Non-Small-Cell Lung Cancer
title_fullStr LncRNAs in Non-Small-Cell Lung Cancer
title_full_unstemmed LncRNAs in Non-Small-Cell Lung Cancer
title_short LncRNAs in Non-Small-Cell Lung Cancer
title_sort lncrnas in non-small-cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549371/
https://www.ncbi.nlm.nih.gov/pubmed/32629922
http://dx.doi.org/10.3390/ncrna6030025
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