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Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review
Previous studies have indicated that genetic variations in individuals may result in changes in gene expression and amino acids. The effect of these changes may lead to different responses to platinum-based chemotherapy. A vast response rate interval and a short survival rate indicate that the effic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549502/ https://www.ncbi.nlm.nih.gov/pubmed/33116759 http://dx.doi.org/10.2147/PGPM.S267625 |
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author | Afifah, Nadiya Nurul Diantini, Ajeng Intania, Ruri Abdulah, Rizky Barliana, Melisa I |
author_facet | Afifah, Nadiya Nurul Diantini, Ajeng Intania, Ruri Abdulah, Rizky Barliana, Melisa I |
author_sort | Afifah, Nadiya Nurul |
collection | PubMed |
description | Previous studies have indicated that genetic variations in individuals may result in changes in gene expression and amino acids. The effect of these changes may lead to different responses to platinum-based chemotherapy. A vast response rate interval and a short survival rate indicate that the efficacy and efficiency of the selection of chemotherapy have not been optimized. This article aims to illustrate the potential relationship of various genetic polymorphisms in response to platinum-based chemotherapy for several types of cancer. This review was conducted using articles from the last three- and five-year periods (2014–2019) that use gene polymorphism and its relationship to the efficacy of platinum-based chemotherapy as their theme. A total of 26 out of 488 relevant articles were included based on specific criteria. Through various mechanisms, genes, including ERCC1, ERCC2/XPD, XPC, XPA, XRCC1, APE-1, PARP1, OGG1, ABCC2, MRP, GSTP1, GSTM1, GSTT1, MATE1, and OCT2, have been associated with patient response to platinum-based chemotherapy. We conclude that genetic polymorphism analysis is recommended for the management of cancer so that each patient can be administered therapy based on his or her genetic profile to achieve an effective and efficient outcome. |
format | Online Article Text |
id | pubmed-7549502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75495022020-10-27 Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review Afifah, Nadiya Nurul Diantini, Ajeng Intania, Ruri Abdulah, Rizky Barliana, Melisa I Pharmgenomics Pers Med Review Previous studies have indicated that genetic variations in individuals may result in changes in gene expression and amino acids. The effect of these changes may lead to different responses to platinum-based chemotherapy. A vast response rate interval and a short survival rate indicate that the efficacy and efficiency of the selection of chemotherapy have not been optimized. This article aims to illustrate the potential relationship of various genetic polymorphisms in response to platinum-based chemotherapy for several types of cancer. This review was conducted using articles from the last three- and five-year periods (2014–2019) that use gene polymorphism and its relationship to the efficacy of platinum-based chemotherapy as their theme. A total of 26 out of 488 relevant articles were included based on specific criteria. Through various mechanisms, genes, including ERCC1, ERCC2/XPD, XPC, XPA, XRCC1, APE-1, PARP1, OGG1, ABCC2, MRP, GSTP1, GSTM1, GSTT1, MATE1, and OCT2, have been associated with patient response to platinum-based chemotherapy. We conclude that genetic polymorphism analysis is recommended for the management of cancer so that each patient can be administered therapy based on his or her genetic profile to achieve an effective and efficient outcome. Dove 2020-10-08 /pmc/articles/PMC7549502/ /pubmed/33116759 http://dx.doi.org/10.2147/PGPM.S267625 Text en © 2020 Afifah et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Afifah, Nadiya Nurul Diantini, Ajeng Intania, Ruri Abdulah, Rizky Barliana, Melisa I Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title | Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title_full | Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title_fullStr | Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title_full_unstemmed | Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title_short | Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review |
title_sort | genetic polymorphisms and the efficacy of platinum-based chemotherapy: review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549502/ https://www.ncbi.nlm.nih.gov/pubmed/33116759 http://dx.doi.org/10.2147/PGPM.S267625 |
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