Oncogenic mutations within the β3‐αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies

BACKGROUND: β3‐αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3‐αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly focus on β3...

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Detalles Bibliográficos
Autores principales: Zhang, Biao, Chen, Yongsheng, Dai, Pingping, Yu, Haoda, Ma, Jianhui, Chen, Chen, Zhang, Yan, Guan, Yanfang, Chen, Rongrong, Liu, Tao, Wang, Jiayin, Yang, Ling, Yi, Xin, Xia, Xuefeng, Ma, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549570/
https://www.ncbi.nlm.nih.gov/pubmed/32757330
http://dx.doi.org/10.1002/mgg3.1395

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