Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives

Anemia is a frequent complication of chronic kidney disease, and its primary cause is erythropoietin deficiency. After diagnosis, treatment begins with administration of an erythropoiesis-stimulating agent (ESA). However, some patients present with resistance to ESA, which needs to be reversed, as i...

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Autores principales: Santos, Elton Jonh Freitas, Dias, Raimunda Sheyla Carneiro, Lima, Janielle Ferreira de Brito, Salgado Filho, Natalino, Miranda dos Santos, Alcione
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549651/
https://www.ncbi.nlm.nih.gov/pubmed/33116754
http://dx.doi.org/10.2147/IJNRD.S239151
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author Santos, Elton Jonh Freitas
Dias, Raimunda Sheyla Carneiro
Lima, Janielle Ferreira de Brito
Salgado Filho, Natalino
Miranda dos Santos, Alcione
author_facet Santos, Elton Jonh Freitas
Dias, Raimunda Sheyla Carneiro
Lima, Janielle Ferreira de Brito
Salgado Filho, Natalino
Miranda dos Santos, Alcione
author_sort Santos, Elton Jonh Freitas
collection PubMed
description Anemia is a frequent complication of chronic kidney disease, and its primary cause is erythropoietin deficiency. After diagnosis, treatment begins with administration of an erythropoiesis-stimulating agent (ESA). However, some patients present with resistance to ESA, which needs to be reversed, as it can increase the risk of death in patients with kidney disease. Therefore, we provide a discussion of the current literature regarding the factors that can modify the response to this class of drugs and the strategies that can be considered to optimize the benefits of treating anemia.
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spelling pubmed-75496512020-10-27 Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives Santos, Elton Jonh Freitas Dias, Raimunda Sheyla Carneiro Lima, Janielle Ferreira de Brito Salgado Filho, Natalino Miranda dos Santos, Alcione Int J Nephrol Renovasc Dis Review Anemia is a frequent complication of chronic kidney disease, and its primary cause is erythropoietin deficiency. After diagnosis, treatment begins with administration of an erythropoiesis-stimulating agent (ESA). However, some patients present with resistance to ESA, which needs to be reversed, as it can increase the risk of death in patients with kidney disease. Therefore, we provide a discussion of the current literature regarding the factors that can modify the response to this class of drugs and the strategies that can be considered to optimize the benefits of treating anemia. Dove 2020-10-08 /pmc/articles/PMC7549651/ /pubmed/33116754 http://dx.doi.org/10.2147/IJNRD.S239151 Text en © 2020 Santos et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Santos, Elton Jonh Freitas
Dias, Raimunda Sheyla Carneiro
Lima, Janielle Ferreira de Brito
Salgado Filho, Natalino
Miranda dos Santos, Alcione
Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title_full Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title_fullStr Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title_full_unstemmed Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title_short Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives
title_sort erythropoietin resistance in patients with chronic kidney disease: current perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549651/
https://www.ncbi.nlm.nih.gov/pubmed/33116754
http://dx.doi.org/10.2147/IJNRD.S239151
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